Genomic Feature
tl43c
- ID
- ZDB-ALT-980203-1588
- Name
- tl43c
- Synonyms
-
- L43C (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 15423926 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Lys>Stop at position 81 (1)
- Flanking Sequence
-
GCCATTGTGCATTAGGAAAAATGCACTACATGTGCAAGATCATTTGTCAAGTCTTATTTTTGCTTTGTCTGGATATGCATTTCCAACTCTCAAAAGTACTGATCACCATTGATTTGTGTTCTGTAAACCCCATCTAAGGGATAATTAACCCTTCAGTTGTCCCAAAGCTATTTTACTTTTTCTTCTGTACAAAACAAGACATTTTAAAGAAAACATGTAACAATCGACTTTAGTATTTGTTTTCCCTACAATGGAAGCCAACGGTTAAAATATATATTTTTAAAAATCTTTACTGTGTTCAAAGAAACTCATAAAGGTTTATAACTATTTCTGGGCGATTAAAATTTAAATTTTGGGTGAACTATTCCTTTAACTTGGCATATGTATCATAGGGTATGTCAATCACCTCAAATTATAAAAACAAGCCAGGAAACATTCATCCACCACAATGTCTCAAAGAGCAAAGCCAATGCAAATGCACTCACCATCAGGTTTTGATT
T/A ACACTCTATTTTAGAAACTCCATGACAAGTGCAAAGAAGCGTGCTGCCCAGATAAATGCGCTCCCACTTCTCTCCAGCTCCATAAAACTGTCCGTCCATAACACATCCATCTGCACAGTACACAACAAAACCTCACTGAGTTTTGCAGCATGTTAACTTTTCCATGATCAAATAAAAATCACACTAAGTAGCAAAAACTAAATACATAAAACTTCATACATCTACACTGAAAAAAATGGATTTGGATTTACTTTTTTTAAGGAAAGTGATATCAAAGAATTTTTATGGGTTGAATTTAAACAAACAAGTTAAACATTACTAAATTTAACCACTTCTTACAAAAAAAAGCAAATCCAATCAATATTTTTTCCAGTGTGCCAGCCTTTATAAAACAATTTGCGTCTGCAAAATAATTATAATACCCATAATAGTAATCATAATAATAAAATAAATGAAATAAACCCAAAGCCAATACACACAGAGTGCCTCCTACCTTGTGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fn1atl43c/tl43c | Homozygous | ♀+/- ♂+/- | 12 figures  from 6 publications | 5 figures from 4 publications | |
| fn1atl43c/tl43c (AB) | Homozygous | ♀+/- ♂+/- | Fig. 7 from Wong et al., 2012 | Fig. 7 from Wong et al., 2012 | |
| fn1atl43c/tl43c (AB/TU) | Homozygous | ♀+/- ♂+/- | 2 figures from Gao et al., 2022 | Fig. 6 from Gao et al., 2022 | |
| fn1atl43c/+ | Heterozygous | ♀+/- ♂+/- | 3 figures from Uribe-Montes et al., 2024 | ||
| fn1atl43c/+ (AB) | Heterozygous | Unknown | |||
| fn1atl43c/tl43c; ha01Tg (AB/TU) | Complex | 2 figures from Gao et al., 2022 | Fig. 1 from Gao et al., 2022 | ||
| fn1atl43c/tl43c; ha01Tg; vu234Tg (AB/TU) | Complex | Fig. 7 from Gao et al., 2022 | Fig. 7 from Gao et al., 2022 | ||
| fn1atl43c/tl43c; itga5tbfe1/tbfe1 (AB/TU) | Complex | Fig. 5 from Gao et al., 2022 | |||
| fn1atl43c/tl43c; itga5tbfe1/tbfe1; ha01Tg (AB/TU) | Complex | Fig. 5 from Gao et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Uribe-Montes, L.C., Sanabria-Camargo, C.A., Piñeros-Romero, C.C., Otálora-Tarazona, S., Ávila-Jiménez, E., Acosta-Virgüez, E., Garavito-Aguilar, Z.V. (2024) Fibronectin and Hand2 influence tubulogenesis during pronephros development and mesonephros regeneration in zebrafish (Danio rerio). PLoS One. 19:e0307390e0307390
- Gao, Y., Hu, B., Flores, R., Xie, H., Lin, F. (2022) Fibronectin and Integrin α5 play overlapping and independent roles in regulating the development of pharyngeal endoderm and cartilage. Developmental Biology. 489:122-133
- Theodore, L.N., Hagedorn, E.J., Cortes, M., Natsuhara, K., Liu, S.Y., Perlin, J.R., Yang, S., Daily, M.L., Zon, L.I., North, T.E. (2017) Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 8(5):1226-1241
- Wang, J., Karra, R., Dickson, A.L., and Poss, K.D. (2013) Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Developmental Biology. 382(2):427-435
- Hayes, J.M., Hartsock, A., Clark, B.S., Napier, H.R., Link, B.A., and Gross, J.M. (2012) Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Molecular biology of the cell. 23(24):4725-4738
- Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S. (2012) Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish. Developmental Biology. 361(2):377-91
- Garavito-Aguilar, Z.V., Riley, H.E., and Yelon, D. (2010) Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development (Cambridge, England). 137(19):3215-3220
- Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106
- Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H., and Stainier, D.Y. (2006) The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development (Cambridge, England). 133(20):4063-4072
- Koshida, S., Kishimoto, Y., Ustumi, H., Shimizu, T., Furutani-Seiki, M., Kondoh, H., and Takada, S. (2005) Integrinalpha5-Dependent Fibronectin Accumulation for Maintenance of Somite Boundaries in Zebrafish Embryos. Developmental Cell. 8(4):587-598
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