Genomic Feature
ihb357
- ID
- ZDB-ALT-190705-10
- Name
- ihb357
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with TALEN
- Lab of Origin
- Zhan Yin Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 2: 37631854 - 37631866 (GRCz11) (1) Details
- Nucleotide change
- GTGTAGACAGACG/AAA
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 3 bp inserted / 13 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGATTTCTTCGCAAAATAAATTAAAAAAAGACAGCACTAGAGGTCTTGACTGATCAGATTAGGGTTTAAAATCCTCTTGCAGCTCCTGTCAGGGCTACAAATGGCTGCATAAAACACGGGCCTGGCTGAACTTGAAAACCAGTTCGGGCTACAAATAGATCAATGTTGTACTCAAACGGTCGATAATCTGGCTTGGGGGCAATGCACACAGTCCGGATAACCTACCATGTCGTTAAAGACAGTTTCGAACGTTTAATCGCAATCAAAACGACCCAACATGGGATTTCTTCGTCCCTTTCACTGCAGTGCCCTCATGTCTGGCTCTGCTCTAGCAAATGTGTGACAGTGGTCAAAATCCACGATCCCCTTTTCGCGTTGCAGGGTGCTTTGTGGATTAACATTTCAACAGACAGACTCGTGTAGTATCATGTAGTATTAAAGACAAAACAGCGGTTAAGTTACACTTACTTTCTCCATTTGTTTGTTGACAGTTGCAAACA
GTGTAGACAGACG/AAA CAACCAAAACAATCAAAGTCCGCAGCCGCATTTTGACCCGCGGTAAAGCCGAAAATCGGTCCAAAAATCCCCTCCGAACTTGTCTTCTTGTGGGTAACGATCAGTTTTAATAGTCCGGTGTTGTTTTAGAAGGATAAAAATTAAAAAGAAAAGAACCCTGTCACCCACCCCTCTGAAAAAAATGGGCGGAGAGGAAAGTTCAACGTGTTCAATCCGCTCTGCTGTCGCGCGCACAGACTGATGCTGATATGAACACGCGCACGAGCGCTAAGCTAATGACAGCGCGTGGCCGCGACTTTCATTTACTGTATCCATACGAATAAAGCATAATTTAAAATGAGCAGCCGCATCATTTCGGATAGCTTGAATGTATTTGTCCAGCACTTGCGCAGTTTGTCCCAAGCCTGGCGAAAAAATGGGGTAAAAAAGCTGGCGATGTGGAATGGCTGCGCACACAGAGCGCAGGCCGAAGTAATCAATAGAGTTTACAAGAGACTTTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| insraihb357/ihb357 | Homozygous | ♀+/- ♂+/- | 6 figures from 2 publications | 4 figures from 2 publications | |
| insraihb357/ihb357 | Homozygous | Unknown | 7 figures from 2 publications | 4 figures from Gong et al., 2018 | |
| insrbihb358/ihb358; insraihb357/ihb357 | Complex | 3 figures from Yang et al., 2017 | 3 figures from Yang et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Gong, Y., Zhai, G., Su, J., Yang, B., Jin, J., Liu, H., Yin, Z., Xie, S., Han, D. (2018) Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. General and comparative endocrinology. 269:33-45
- Yang, B., Zhai, G., Gong, Y., Su, J., Han, D., Yin, Z., and Xie, S. (2017) Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science Bulletin. 62(7):486-492
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
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