Genomic Feature
sa280
- ID
- ZDB-ALT-160129-6
- Name
- sa280
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Stemple Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 21684395 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>STOP at position 37 (1)
- Flanking Sequence
-
GTGACAGCGTTTCCCCCGGAGAGTCAAGAGACTATTCCGATTCACCTGTCTTTGCAGTACCCAAGAACTGCAGGTGTAGCACATACAGTCGCAGGTAAACAGAACATGTTTGCCAAGGGCATTGATTTGAGCGTGGTCAGTTCTGTTCAATTATTGTCAAAGCGCGGAGCAGTCGAAAGGAAACATGAACAGAATCTACTGCCAGTTGACAGCTTTGTGTAAACAGTGAAACCAATGGTGCGGCAGGGTCACATGGTCACGATGGCACACCTATGAGGCCCCGAGCGGCGCCAGACGCTCAGACTGCAGGTAGAGCAGAGGTCCTGATCAGGGGCAGGGCGCTGGCTCATGTGCTCGTGTACGGCACGGTTTCCCCGGTCTATGGCAATCATGAATCGGGAAGAGCATTACTATCCGCCTAACCACCTGTACAAGGACTCTTGTGCCTTCCAGAGACACCCCAACGAAGACTACAGCCAAAACCCTCCACCGTGTCTTTA
T/A ATGAGACAGGCACATTCAGTATACGCCTCACCATTGGGCGCACAGGACCAGCCAAATCTTACCGACATTACTTCTTATAACATGTCGAGCCGGTATGATCTGGCAGGGCCTCATCTTCACCTTCCCCAAACTTCACAGACATCTCTACAGTCGCTCGGGGGTTACGGAGACTCTCTGGACCTCTGCGGGGATCGGAACAGATACCATCTCCCATTTCCGTGGATGAAGTCAACCAAATCTCACACGCACGCATGGAAAGGACAGTGGACAGGTAACTCGTACTTTGGCCATTAATCTTTGTTCACCAAATAACTCCTGATTGCAGGCCATCAAGTCAAATTCATGCCTATGATGTTCCAAATCAATCTAAACATTTGTTCCGTTTCAAGAGGTACAGGTTAGTTGATTAAAGTTAAAAATGCCAGTCCACTGATGCTTAGTAAAAACTAAATCTTTGACTACCTGTTGTATTGCCTGTTGTATATGAACAGTTGTGTTGC - Additional Sequence
- None
Fish
from 3 publications1 - 10 of 11
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Supplemental Information
- Genotyping protocol
- None
- Schmitner, N., Recheis, C., Thönig, J., Kimmel, R.A. (2021) Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia. Cells. 10(11):
- Titialii-Torres, K.F., Morris, A.C. (2021) Embryonic hyperglycemia perturbs the development of specific retinal cell types, including photoreceptors. Journal of Cell Science. 135(1):
- Ali, Z., Zang, J., Lagali, N., Schmitner, N., Salvenmoser, W., Mukwaya, A., Neuhauss, S.C.F., Jensen, L.D., Kimmel, R.A. (2020) Photoreceptor Degeneration Accompanies Vascular Changes in a Zebrafish Model of Diabetic Retinopathy. Investigative ophthalmology & visual science. 61:43
- Wiggenhauser, L.M., Qi, H., Stoll, S.J., Metzger, L., Bennewitz, K., Poschet, G., Krenning, G., Hillebrands, J.L., Hammes, H.P., Kroll, J. (2020) Activation of retinal angiogenesis in hyperglycemic pdx1-/- zebrafish mutants. Diabetes. 69(5):1020-1031
- Helker, C.S.M., Mullapudi, S.T., Mueller, L.M., Preussner, J., Tunaru, S., Skog, O., Kwon, H.B., Kreuder, F., Lancman, J.J., Bonnavion, R., Dong, P.D.S., Looso, M., Offermanns, S., Korsgren, O., Spagnoli, F.M., Stainier, D.Y.R. (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development (Cambridge, England). 146(14):
- Kimmel, R.A., Dobler, S., Schmitner, N., Walsen, T., Freudenblum, J., Meyer, D. (2015) Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment. Scientific Reports. 5:14241
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