Genomic Feature
t22598
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 31407085 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 22598 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 580 (1)
- Flanking Sequence
-
GATTTTAATCACTCATACTATCCAAATTTAACTGTCTATTCCAAGTAAAATATGAGGAAATTTCACTGTAAGTAATTATGCAGTGTCTGTCCTTGAAATGCCCAATAAAGGGATGGTTCTCCCAAAACTGAAAAATTTGTCAATATTTACTCACCCTTCACTTGTTTACAACCTATTTGAGTTTCTTTCTTCTGTTGAACACAAAAAAATGCATTTTGAAGAAAGCTGGGAACCTGGAAAAATGTACTTCCATGGTATTTGTTTTTCCTACTATGAATTTCAATGGTTACAGGATTTCAGCTTTCTTCAGAATATCTTCTTTTTTGTGTTTAAGAGAAATAAAGAAACTGTTTTGAACACGCATAAGGGTCAATAAATGAGGATTTAACTTTCATTTTTGGATGAACTGTCCCTTTAAATAGTCACCTATACTTTTAGAGATATTGTCCCCCATCTTATCTTGTATGTGACGTTGTCTTATTTAGGGTGAACATTTGGGT
C/T GAGGCACAAGGACAAACATCTATGCTGGTATTCTGAAGCCGAAGAGTGATGATGAAGATGATCTGGGAGGATACTCGCAGGAGGTGAAAGTGGTTTTGAAGGTGCTGGGCTCAGGACATAGAGATATTTCTCTGGTAAGAAGAGCATCTAGAAATACAAAACCTTGTCACGACCAAACAAGATGATCGTTTTCAGAGATTGTGATATTTTATTTCTGACTTGTTTATTTATTTTTATTTTTTGCAAGTTTTGGATAAAAGTGCCTGTTTTATCATAAAAAAAAGATTAGACAGCTATCTCTAAACAAAACAAGACATTTGTAAACATTAGAGATGTGTTTCACTACAACTCATTCTACAACAGAAAAAAAAACATAATTTTAGAACTATTCAGAAAAGAAAAAATGAAATAAAACAAACATGTTGTAGTGACAGTCACTCTCCGTATGCATTTTATATATCAAATTTAAAGAATATTAAATATAAATATAAAGTCCTATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| jak1t22598/t22598 | Homozygous | ♀+/- ♂+/- | 2 figures from Iwanami et al., 2011 | 2 figures from Iwanami et al., 2011 | |
| jak1t22598/t22598; fr101Tg | Complex | Fig. 1 from Iwanami et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
- Iwanami, N., Mateos, F., Hess, I., Riffel, N., Soza-Ried, C., Schorpp, M., and Boehm, T. (2011) Genetic Evidence for an Evolutionarily Conserved Role of IL-7 Signaling in T Cell Development of Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 186(12):7060-6
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