Gene
jak1
- ID
- ZDB-GENE-980526-142
- Name
- Janus kinase 1
- Symbol
- jak1 Nomenclature History
- Previous Names
-
- etID309794.6 (1)
- fb93e10
- jak1 kinase
- wu:fb93e10
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within T cell differentiation in thymus. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytosol. Is expressed in cranial ganglion; otic vesicle; somite; and vasculature. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55268 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Iwanami et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-jak1 | N/A | Conway, 2006 |
| MO2-jak1 | N/A | Iwanami et al., 2011 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammation, immune dysregulation, and eosinophilia | 618999 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041046 | JAK, FERM F2 lobe domain |
| Domain | IPR041155 | FERM F1 lobe ubiquitin-like domain |
| Domain | IPR041381 | JAK1-3/TYK2, pleckstrin homology-like domain |
| Family | IPR016251 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
| Family | IPR020776 | Tyrosine-protein kinase, non-receptor Jak1 |
| Family | IPR051286 | Janus Kinase (JAK) |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK, FERM F2 lobe domain | Janus Kinase (JAK) | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor Jak1 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU16 | InterPro | 1153 | ||||||||||||||||||
| UniProtKB:O12990 | InterPro | 1153 |
Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ubb:LOXP-BFP-LOXP-jak1_L910P-FLAG,cryaa:Cerulean) |
| 3 | Yuan et al., 2016 | ||
| Tg(ubb:LOXP-BFP-LOXP-jak1_S703I-FLAG,cryaa:Cerulean) |
| 3 | Yuan et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-201N5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-202I2 | ZFIN Curated Data | |
| Encodes | EST | fb93e10 | ||
| Encodes | cDNA | MGC:55268 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131073 (1) | 3854 nt | ||
| Genomic | GenBank:AL954175 (1) | 176268 nt | ||
| Polypeptide | UniProtKB:O12990 (1) | 1153 aa |
- Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666
- Guo, Q.Q., Yuan, Y.Y., Sun, T.W., Wu, S.J., Li, X.H., Zhao, H.S. (2023) Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway. European review for medical and pharmacological sciences. 27:425442684254-4268
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Basheer, F., Bulleeraz, V., Ngo, V.Q.T., Liongue, C., Ward, A.C. (2022) In vivo impact of JAK3 A573V mutation revealed using zebrafish. Cellular and molecular life sciences : CMLS. 79:322
- Cheng, B., Zou, L., Zhang, H., Cao, Z., Liao, X., Shen, T., Xiong, G., Xiao, J., Liu, H., Lu, H. (2021) Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio). Chemosphere. 263:127849
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Shimizu, Y., Kiyooka, M., Ohshima, T. (2021) Transcriptome Analyses Reveal IL6/Stat3 Signaling Involvement in Radial Glia Proliferation After Stab Wound Injury in the Adult Zebrafish Optic Tectum. Frontiers in cell and developmental biology. 9:668408
- Zhang, X.H., Zhou, C.C., Li, C.Y., Hua, Y., Li, K., Wei, P., He, M.F. (2021) Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 83:153469
- Duan, J., Liang, S., Yu, Y., Li, Y., Wang, L., Wu, Z., Chen, Y., Miller, M.R., Sun, Z. (2018) Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Nanotoxicology. 12(5):470-484
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