| ZFIN ID: ZDB-EXP-241204-4 |
Experiment Conditions Description: resection: cardiac ventricle, chemical treatment: clodronic acid
| resection: cardiac ventricle |
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| Name: | resection |
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| Synonyms: | |
| Definition: | Surgical manipulation in which a particular organ, appendage, or part of an organism is removed. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000171] |
| Name: | cardiac ventricle |
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| Synonyms: | ventricle |
| Definition: | Cavitated compound organ that receives blood flow from the atrium and delivers blood to the body via the aorta. Valves are present to direct flow. There are only two chambers present in the fish heart. |
| Ontology: | Anatomy Ontology [ZFA:0000009] |
| chemical treatment: clodronic acid |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | clodronic acid |
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| Synonyms: | (Dichloro-phosphono-methyl)-phosphonic acid, (dichloromethanediyl)bis(phosphonic acid), (dichloromethylene)bisphosphonic acid, (dichloromethylene)diphosphonic acid, acide clodronique, acido clodronico, acidum clodronicum, clodronate, clodronic acid, clodronsaeure, dichloromethylene-1,1-bisphosphonic acid, dichloromethylene-1,1-diphosphonic acid, dichloromethylidene diphosphonate |
| Definition: | An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. |
| Ontology: | ChEBI [CHEBI:110423] ( EBI ) |
| Publication: | Ma et al., 2021 |
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