clodronic acid

Term ID

CHEBI:110423

Synonyms

(Dichloro-phosphono-methyl)-phosphonic acid
(dichloromethanediyl)bis(phosphonic acid)
(dichloromethylene)bisphosphonic acid
(dichloromethylene)diphosphonic acid
acide clodronique
acido clodronico
acidum clodronicum
clodronate
clodronic acid
clodronsaeure
dichloromethylene-1,1-bisphosphonic acid
dichloromethylene-1,1-diphosphonic acid
dichloromethylidene diphosphonate

Definition

An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.

References

Beilstein:1876367
CAS:10596-23-3
DrugBank:DB00720
Drug_Central:690
KEGG:D03545
LINCS:LSM-5802
PMID:15658873
PMID:7818726
PMID:8421279
Patent:BE672205

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 1,1-bis(phosphonic acid) one-carbon compound organochlorine compound

1,1-bis(phosphonic acid) one-carbon compound organochlorine compound Show first 5 Terms
has_role: antineoplastic agent bone density conservation agent

antineoplastic agent bone density conservation agent Show first 5 Terms
inverse is_conjugate_base_of: clondronate(2-)

clondronate(2-) Show first 5 Terms
is_conjugate_acid_of: clondronate(2-)

clondronate(2-) Show first 5 Terms

Phenotype

Phenotype resulting from clodronic acid

Phenotype where environments contain clodronic acid

Phenotype modified by environments containing clodronic acid

Human Disease / Model Data

Citations