ZFIN

ZFIN ID: ZDB-EXP-091029-8

Experiment Conditions Description: chemical treatment: sirolimus, chemical treatment: pepstatin A, chemical treatment: 3-methyladenine, chemical treatment: aloxistatin

chemical treatment: sirolimus

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	sirolimus
Synonyms:	(-)-Rapamycin, (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tet, (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-ep, Antibiotic AY 22989, Rapamune, rapamycin, Sirolimus, sirolimusum
Definition:	A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Ontology:	ChEBI [CHEBI:9168] ( EBI )

chemical treatment: pepstatin A

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	pepstatin A
Synonyms:	(3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-methyl-4-[(2S)-3-methyl-2-[(2S)-3-methyl-2-(3-methylbutanamido)butanamido]butanamido]heptanamido]propanamido]-6-methylheptanoic acid, ahpatinin C, N-(3-methylbutanoyl)-L-valyl-N-[(3S,4S)-1-{[(2S)-1-{[(2S,3S)-1-carboxy-2-hydroxy-5-methylhexan-3-yl]amino}-1-oxopropan-2-yl]amino}-3-hydroxy-6-methyl-1-oxoheptan-4-yl]-L-valinamide, pepsin inhibitor S 735A, pepstatin, pepstatina, pepstatine, pepstatinum, procidin S 735A
Definition:	A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.
Ontology:	ChEBI [CHEBI:7989] ( EBI )

chemical treatment: 3-methyladenine

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	3-methyladenine
Synonyms:	3-methyl-3H-adenine, 3-methyl-3H-purin-6-amine, 3-METHYL-3H-PURIN-6-YLAMINE, 3-Methyladenine, 6-amino-3-methylpurine
Definition:	A methyladenine that is adenine substituted with a methyl group at position N-3.
Ontology:	ChEBI [CHEBI:38635] ( EBI )

chemical treatment: aloxistatin

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	aloxistatin
Synonyms:	aloxistatin, aloxistatina, aloxistatine, aloxistatinum, E 64d, E-64d, E64d, Ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate, ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate, Loxistatin
Definition:	An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide.
Ontology:	ChEBI [CHEBI:101381] ( EBI )

Publication:	He et al., 2009