sirolimus

Term ID

CHEBI:9168

Synonyms

• (-)-Rapamycin
• (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tet
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-ep
• Antibiotic AY 22989
• Rapamune
• rapamycin
• sirolimus
• sirolimusum

Definition

A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.

References

• CAS:53123-88-9
• DrugBank:DB00877
• Drug_Central:2446
• HMDB:HMDB0015015
• KEGG:C07909
• KEGG:D00753
• KNApSAcK:C00018055
• LIPID_MAPS_instance:LMPK06000003
• PDBeChem:RAP
• PMID:19587680
• PMID:22960739
• PMID:22981852
• PMID:22984623
• PMID:24341993
• PMID:24409289
• Reaxys:5848501
• Wikipedia:Rapamycin

Ontology

ChEBI  ( EBI )

Resources

CTD