| ZFIN ID: ZDB-EXP-260313-1 |
Experiment Conditions Description: chemical treatment by injection: clodronic acid, cryoablation: liver
| chemical treatment by injection: clodronic acid |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | clodronic acid |
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| Synonyms: | (Dichloro-phosphono-methyl)-phosphonic acid, (dichloromethanediyl)bis(phosphonic acid), (dichloromethylene)bisphosphonic acid, (dichloromethylene)diphosphonic acid, acide clodronique, acido clodronico, acidum clodronicum, clodronate, clodronic acid, clodronsaeure, dichloromethylene-1,1-bisphosphonic acid, dichloromethylene-1,1-diphosphonic acid, dichloromethylidene diphosphonate |
| Definition: | An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. |
| Ontology: | ChEBI [CHEBI:110423] ( EBI ) |
| cryoablation: liver |
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| Name: | cryoablation |
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| Synonyms: | |
| Definition: | Experimental condition which uses a cold instrument to ablate an anatomical structure or cell. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000249] |
| Name: | liver |
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| Synonyms: | |
| Definition: | Solid compound organ with three lobes that has many functions including bile production, blood detoxification, the production of critical plasma proteins and clotting factors, complement proteins and the storage of many substances, such as lipids, amino acids, iron, and glycogen. Female fish produce vitellogenins in the liver. |
| Ontology: | Anatomy Ontology [ZFA:0000123] |
| Publication: | Sande-Melon et al., 2024 |
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