TALEN

TALEN1-klf2a

ID

ZDB-TALEN-160909-1

Name

TALEN1-klf2a

Previous Names

None

Target

klf2a (1)

Target Sequence 1

5' - ACCGTCTATTTCCACA - 3'

Target Sequence 2

5' - CACGTTCTCCCAGCAT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
ig4	klf2a

Expression

Gene expression in Wild Types + TALEN1-klf2a

No data available

Phenotype

Phenotype resulting from TALEN1-klf2a

No data available

Phenotype of all Fish created by or utilizing TALEN1-klf2a

Phenotype	Fish	Conditions	Figures
bulbus arteriosus wnt9b expression decreased amount, abnormal	klf2a^ig4/ig4	standard conditions	Fig. 7 from Goddard et al., 2017
atrioventricular valve wnt9b expression absent, abnormal	klf2a^ig4/ig4	standard conditions	Fig. 7 from Goddard et al., 2017
atrioventricular valve morphology, abnormal	klf2a^ig4/ig4 (AB)	control	Fig. 6 from Steed et al., 2016
atrioventricular canal fn1b expression decreased amount, abnormal	klf2a^ig4/ig4 (AB)	control	Fig. 7 from Steed et al., 2016
atrioventricular valve morphogenesis decreased process quality, abnormal	klf2a^ig4/ig4; rk8Tg; ubs3Tg	control	Fig. 6 from Steed et al., 2016
atrioventricular valve development process quality, abnormal	klf2a^ig4/ig4; rk8Tg; ubs3Tg	control	Fig. 6 from Steed et al., 2016
cardiac jelly cell disorganized, abnormal	klf2a^ig4/ig4; rk8Tg; ubs3Tg	control	Fig. 6 from Steed et al., 2016
ventriculo bulbo valve morphogenesis delayed, abnormal	klf2a^ig4/ig4; rk8Tg; ubs3Tg	standard conditions	Figure 7 from Duchemin et al., 2019
atrioventricular valve morphology, abnormal	klf2a^ig4/ig4; rk8Tg; ubs3Tg	control	Fig. 6 from Steed et al., 2016
atrioventricular canal ab2-fn labeling decreased amount, abnormal	klf2a^ig4/ig4; ubs10Tg	control	Fig. 7 from Steed et al., 2016
bulbus arteriosus endocardial cushion EGFP expression decreased amount, abnormal	klf2a^ig4/ig4; um14Tg	standard conditions	Figure 7 from Duchemin et al., 2019
ventriculo bulbo valve posterior region EGFP expression decreased amount, abnormal	klf2a^ig4/ig4; um14Tg	standard conditions	Figure 7 from Duchemin et al., 2019
ventriculo bulbo valve Notch signaling involved in heart development decreased process quality, abnormal	klf2a^ig4/ig4; um14Tg	standard conditions	Figure 7 from Duchemin et al., 2019
regenerating tissue d2EGFP expression amount, ameliorated	klf2a^ig4/ig4; mw43Tg; s957Tg	chemical ablation: cardiac ventricle, chemical treatment by environment: metronidazole	Figure 5 from Gálvez-Santisteban et al., 2019
regenerating tissue notch1b expression amount, ameliorated	klf2a^ig4/ig4; s957Tg	chemical ablation: cardiac ventricle, chemical treatment by environment: metronidazole	Figure 5 from Gálvez-Santisteban et al., 2019
atrium cardiac muscle cell proliferation occurrence, ameliorated	klf2a^ig4/ig4; s957Tg	chemical ablation: cardiac ventricle, chemical treatment by environment: metronidazole	Figure 5 from Gálvez-Santisteban et al., 2019
cardiac ventricle cardiac muscle cell proliferation occurrence, ameliorated	klf2a^ig4/ig4; s957Tg	chemical ablation: cardiac ventricle, chemical treatment by environment: metronidazole	Figure 5 from Gálvez-Santisteban et al., 2019
heart regeneration decreased process quality, abnormal	klf2a^ig4/ig4; s957Tg	chemical ablation: cardiac ventricle, chemical treatment by environment: metronidazole	Figure 5 from Gálvez-Santisteban et al., 2019
brain vasculature morphology, ameliorated	klf2a^ig4/ig4; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	standard conditions	Figure 7 from Li et al., 2021

Citations