PUBLICATION
Patterning during organogenesis: genetic analysis of cardiac chamber formation
- Authors
- Yelon, D. and Stainier, D.Y.
- ID
- ZDB-PUB-990507-4
- Date
- 1999
- Source
- Seminars in cell & developmental biology 10(2): 93-98 (Review)
- Registered Authors
- Stainier, Didier, Yelon, Deborah
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics*
- Cell Lineage/genetics
- Genes
- Genetic Testing
- Heart Atria/embryology*
- Heart Ventricles/embryology*
- Models, Biological
- Mutation
- Signal Transduction/genetics
- Tretinoin/physiology
- Zebrafish/embryology
- PubMed
- 10355033 Full text @ Sem. Cell Dev. Biol.
Citation
Yelon, D. and Stainier, D.Y. (1999) Patterning during organogenesis: genetic analysis of cardiac chamber formation. Seminars in cell & developmental biology. 10(2):93-98.
Abstract
A classical genetic approach, in which mutagenized organisms are screened for phenotypes of interest, is appealing for the analysis of developmental processes. Here, we describe the advantages of zebrafish genetics for the study of heart development. As an example of the utility of this strategy, we discuss its potential to illuminate the molecular mechanisms of cardiac chamber formation. The signals that specify ventricular and atrial lineages and the differentiation pathways that produce distinct chambers are poorly understood. Recently identified zebrafish mutations that disrupt ventricular or atrial development promise to reveal genes essential for these processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping