ZFIN Person: Yelon, Deborah

ZFIN ID: ZDB-PERS-970313-33

Yelon, Deborah

Email:	dyelon@ucsd.edu
URL:	http://www.biology.ucsd.edu/labs/yelon/
Affiliation:	Yelon Lab
Address:	Professor Division of Biological Sciences University of California, San Diego 9500 Gilman Drive, #0347 La Jolla, CA 92093-0347
Country:	United States
Phone:	858-534-1822
Fax:	858-822-4612
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Yao, Y., Marra, A.N., Yelon, D. (2021) Pathways Regulating Establishment and Maintenance of Cardiac Chamber Identity in Zebrafish. Journal of cardiovascular development and disease. 8(2):

Espanola, S.G., Song, H., Ryu, E., Saxena, A., Kim, E.S., Manegold, J.E., Nasamran, C.A., Sahoo, D., Oh, C.K., Bickers, C., Shin, U., Grainger, S., Park, Y.H., Pandolfo, L., Kang, M.S., Kang, S., Myung, K., Cooper, K.L., Yelon, D., Traver, D., Lee, Y. (2020) Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nature cell biology. 22(12):1411-1422

Sidhwani, P., Leerberg, D.M., Boezio, G.L.M., Capasso, T.L., Yang, H., Chi, N.C., Roman, B.L., Stainier, D.Y.R., Yelon, D. (2020) Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Development (Cambridge, England). 147(12):

Begovich, K., Yelon, D., Wilhelm, J.E. (2020) Phosphoribosyl pyrophosphate synthetase polymerization influences lens fiber organization in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 249(8):1018-1031

Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113

Hernandez, L., Ryckebüsch, L., Wang, C., Ling, R., Yelon, D. (2019) Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid. Developmental dynamics : an official publication of the American Association of Anatomists. 248(12):1195-1210

Ren, J., Han, P., Ma, X., Farah, E.N., Bloomekatz, J., Zeng, X.I., Zhang, R., Swim, M.M., Witty, A.D., Knight, H.G., Deshpande, R., Xu, W., Yelon, D., Chen, S., Chi, N.C. (2019) Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes. Developmental Cell. 50(6):729-743.e5

Gordon, W.E., Espinoza, J.A., Leerberg, D.M., Yelon, D., Hamdoun, A. (2019) Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquatic toxicology (Amsterdam, Netherlands). 212:88-97

Sidhwani, P., Yelon, D. (2019) Fluid forces shape the embryonic heart: Insights from zebrafish. Current topics in developmental biology. 132:395-416

Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000

Pradhan, A., Zeng, X.I., Sidhwani, P., Marques, S.R., George, V., Targoff, K.L., Chi, N.C., Yelon, D. (2017) FGF signaling enforces cardiac chamber identity in the developing ventricle. Development (Cambridge, England). 144(7):1328-1338

Iklé, J.M., Tavares, A.L., King, M., Ding, H., Colombo, S., Firulli, B.A., Fiulli, A.B., Targoff, K.L., Yelon, D., Clouthier, D.E. (2017) Nkx2.5 regulates Endothelin Converting Enzyme-1 during pharyngeal arch patterning. Genesis (New York, N.Y. : 2000). 55(3)

Bloomekatz, J., Singh, R., Prall, O.W., Dunn, A.C., Vaughan, M., Loo, C.S., Harvey, R.P., Yelon, D. (2017) Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. eLIFE. 6

Perens, E.A., Garavito-Aguilar, Z.V., Guio-Vega, G.P., Peña, K.T., Schindler, Y.L., Yelon, D. (2016) Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. eLIFE. 5

Ryckebüsch, L., Hernandez, L., Wang, C., Phan, J., Yelon, D. (2016) Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment. Development (Cambridge, England). 143(16):2965-72

Houk, A.R., Yelon, D. (2016) Strategies for analyzing cardiac phenotypes in the zebrafish embryo. Methods in cell biology. 134:335-68

Schindler, Y.L., Garske, K.M., Wang, J., Firulli, B.A., Firulli, A.B., Poss, K.D., Yelon, D. (2014) Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development (Cambridge, England). 141(16):3112-22

Zeng, X.X., Yelon, D. (2014) Cadm4 Restricts the Production of Cardiac Outflow Tract Progenitor Cells. Cell Reports. 7(4):951-60

Schumacher, J.A., Bloomekatz, J., Garavito-Aguilar, Z.V., and Yelon, D. (2013) tal1 regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Developmental Biology. 383(2):214-226

Targoff, K.L., Colombo, S., George, V., Schell, T., Kim, S.H., Solnica-Krezel, L., and Yelon, D. (2013) Nkx genes are essential for maintenance of ventricular identity. Development (Cambridge, England). 140(20):4203-4213

Miura, G.I., and Yelon, D. (2013) Cardiovascular biology: play it again, gata4. Current biology : CB. 23(14):R619-621

Zhang, R., Han, P., Yang, H., Ouyang, K., Lee, D., Lin, Y.F., Ocorr, K., Kang, G., Chen, J., Stainier, D.Y., Yelon, D., and Chi, N.C. (2013) In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 498(7455):497-501

Giurumescu, C.A., Kang, S., Planchon, T.A., Betzig, E., Bloomekatz, J., Yelon, D., Cosman, P., and Chisholm, A.D. (2012) Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development (Cambridge, England). 139(22):4271-4279

Yelon, D. (2012) Developmental biology: Heart under construction. Nature. 484(7395):459-460

Lin, Y.F., Swinburne, I., and Yelon, D. (2012) Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Developmental Biology. 362(2):242-253

Totong, R., Schell, T., Lescroart, F., Ryckebüsch, L., Lin, Y.F., Zygmunt, T., Herwig, L., Krudewig, A., Gershoony, D., Belting, H.G., Affolter, M., Torres-Vazquez, J., and Yelon, D. (2011) The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development (Cambridge, England). 138(19):4199-4205

Wang, J., Panáková, D., Kikuchi, K., Holdway, J.E., Gemberling, M., Burris, J.S., Singh, S.P., Dickson, A.L., Lin, Y.F., Sabeh, M.K., Werdich, A.A., Yelon, D., MacRae, C.A., and Poss, K.D. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development (Cambridge, England). 138(16):3421-30

Waxman, J.S., and Yelon, D. (2011) Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Developmental Biology. 352(1):128-140

Peshkovsky, C., Totong, R., and Yelon, D. (2011) Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 240(2):446-456

Miura, G.I., and Yelon, D. (2011) A guide to analysis of cardiac phenotypes in the zebrafish embryo. Methods in cell biology. 101:161-180

Sogah, V.M., Serluca, F.C., Fishman, M.C., Yelon, D.L., MacRae, C.A., and Mably, J.D. (2010) Distinct troponin C isoform requirements in cardiac and skeletal muscle. Developmental dynamics : an official publication of the American Association of Anatomists. 239(11):3115-3123

Garavito-Aguilar, Z.V., Riley, H.E., and Yelon, D. (2010) Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development (Cambridge, England). 137(19):3215-3220

Mandel, E.M., Kaltenbrun, E., Callis, T.E., Zeng, X.X., Marques, S.R., Yelon, D., Wang, D.Z., and Conlon, F.L. (2010) The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development (Cambridge, England). 137(11):1919-1929

Waxman, J.S., and Yelon, D. (2009) Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling. Developmental dynamics : an official publication of the American Association of Anatomists. 238(5):1207-1213

de Pater, E., Clijsters, L., Marques, S.R., Lin, Y.F., Garavito-Aguilar, Z.V., Yelon, D., and Bakkers, J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development (Cambridge, England). 136(10):1633-1641

Marques, S.R., and Yelon, D. (2009) Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Developmental Biology. 328(2):472-482

Mich, J.K., Blaser, H., Thomas, N.A., Firestone, A.J., Yelon, D., Raz, E., and Chen, J.K. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328(2):342-354

Linville, A., Radtke, K., Waxman, J.S., Yelon, D., and Schilling, T.F. (2009) Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Developmental Biology. 325(1):60-70

Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D., and Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current biology : CB. 18(23):1882-1888

Waxman, J.S., Keegan, B.R., Roberts, R.W., Poss, K.D., and Yelon, D. (2008) Hoxb5b acts downstream of retinoic Acid signaling in the forelimb field to restrict heart field potential in zebrafish. Developmental Cell. 15(6):923-934

de Campos-Baptista, M.I., Holtzman, N.G., Yelon, D., and Schier, A.F. (2008) Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3624-3633

Thomas, N.A., Koudijs, M., van Eeden, F.J., Joyner, A.L., and Yelon, D. (2008) Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development (Cambridge, England). 135(22):3789-3799

Targoff, K.L., Schell, T., and Yelon, D. (2008) Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Developmental Biology. 322(2):314-321

Marques, S.R., Lee, Y., Poss, K.D., and Yelon, D. (2008) Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. Developmental Biology. 321(2):397-406

Schoenebeck, J.J., Keegan, B.R., and Yelon, D. (2007) Vessel and blood specification override cardiac potential in anterior mesoderm. Developmental Cell. 13(2):254-267

Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879

Holtzman, N.G., Schoenebeck, J.J., Tsai, H.J., and Yelon, D. (2007) Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development (Cambridge, England). 134(13):2379-2386

Auman, H.J., Coleman, H., Riley, H.E., Olale, F., Tsai, H.J., and Yelon, D. (2007) Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes. PLoS Biology. 5(3):e53

Schoenebeck, J.J., and Yelon, D. (2007) Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Seminars in cell & developmental biology. 18(1):27-35

Waxman, J.S., and Yelon, D. (2007) Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Developmental dynamics : an official publication of the American Association of Anatomists. 236(2):587-595

Ebert, A.M., Hume, G.L., Warren, K.S., Cook, N.P., Burns, C.G., Mohideen, M.A., Siegal, G., Yelon, D., Fishman, M.C., and Garrity, D.M. (2005) Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proceedings of the National Academy of Sciences of the United States of America. 102(49):17705-17710

Trinh, L.A., Yelon, D., and Stainier, D.Y. (2005) Hand2 regulates epithelial formation during myocardial diferentiation. Current biology : CB. 15(5):441-446

Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005) Retinoic acid signaling restricts the cardiac progenitor pool. Science (New York, N.Y.). 307(5707):247-249

Keegan, B.R., Meyer, D., and Yelon, D. (2004) Organization of cardiac chamber progenitors in the zebrafish blastula. Development (Cambridge, England). 131(13):3081-3091

Auman, H.J., and Yelon, D. (2004) Vertebrate organogenesis: getting the heart into shape. Current biology : CB. 14(4):R152-153

O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004) Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology. 265(1):246-261

Berdougo, E., Coleman, H., Lee, D.H., Stainier, D.Y., and Yelon, D. (2003) Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development (Cambridge, England). 130(24):6121-6129

Miller, C.T., Yelon, D., Stainier, D.Y., and Kimmel, C.B. (2003) Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development (Cambridge, England). 130(7):1353-1365

Glickman, N.S. and Yelon, D. (2002) Cardiac development in zebrafish: coordination of form and function. Seminars in cell & developmental biology. 13(6):507-513

Yelon, D. and Stainier, D.Y.R. (2002) Pattern formation: swimming in retinoic acid. Current biology : CB. 12(2):R707-709

Glickman, N.S. and Yelon, D. (2002) Analysis of the cellular behaviors driving cardiac fusion in zebrafish. Developmental Biology. 247(2):473

Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y., and Yelon, D. (2002) The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development (Cambridge, England). 129(7):1623-1632

Yelon, D., Weinstein, B.M., and Fishman, M.C. (2002) Cardiovascular system. Results and problems in cell differentiation. 40:298-321

Yelon, D., Feldman, J.L., and Keegan, B.R. (2002) Genetic regulation of cardiac patterning in zebrafish. Cold Spring Harbor symposia on quantitative biology. 67:19-25

Yelon, D. (2001) Cardiac patterning and morphogenesis in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 222(4):552-563

Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., and Stainier, D.Y. (2001) casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development. 15(12):1493-1505

Yelon, D. (2001) Patterning during organogenesis: Cardiac chamber formation in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A715

Yelon, D., Ticho, B., Halpern, M.E., Ruvinsky, I., Ho, R.K., Silver, L.M., and Stainier, D.Y. (2000) The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development (Cambridge, England). 127(12):2573-2582

Kikuchi, Y., Trinh, L.A., Reiter, J.F., Alexander, J., Yelon, D., and Stainier, D.Y.R. (2000) The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development. 14(10):1279-1289

Griffin, K.J., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y., and Kimelman, D. (2000) A conserved role for H15-related T-Box transcription factors in zebrafish and Drosophila heart formation. Developmental Biology. 218(2):235-247

Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., and Stainier, D.Y. (1999) Gata5 is required for the development of the heart and endoderm in zebrafish. Genes & Development. 13(22):2983-2995

Yelon, D., Horne, S.A., and Stainier, D.Y.R. (1999) Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Developmental Biology. 214(1):23-37

Yelon, D. and Stainier, D.Y. (1999) Patterning during organogenesis: genetic analysis of cardiac chamber formation. Seminars in cell & developmental biology. 10(2):93-98

Alexander, J., Stainier, D.Y.R., and Yelon, D. (1998) Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Developmental genetics. 22:288-299

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