PUBLICATION
Hematopoietic mutations in the zebrafish
- Authors
- Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C.
- ID
- ZDB-PUB-970210-26
- Date
- 1996
- Source
- Development (Cambridge, England) 123: 303-309 (Journal)
- Registered Authors
- Abdelilah-Seyfried, Salim, Driever, Wolfgang, Fishman, Mark C., Malicki, Jarema, Schier, Alexander, Solnica-Krezel, Lilianna, Stainier, Didier, Stemple, Derek L., Weinstein, Brant M.
- Keywords
- primitive haematopoiesis; mutations; zebrafish
- MeSH Terms
-
- Hemolysis/genetics
- Cell Differentiation/genetics
- Embryo, Nonmammalian/blood supply
- Hematopoiesis/genetics*
- Light/adverse effects
- Animals
- Blood Cells/pathology
- Mutation*
- Zebrafish/blood
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 9007250 Full text @ Development
Citation
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C. (1996) Hematopoietic mutations in the zebrafish. Development (Cambridge, England). 123:303-309.
Abstract
We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping