PUBLICATION
Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells
- Authors
- He, X., Xiong, D., Zhao, L., Fu, J., Luo, L.
- ID
- ZDB-PUB-240703-4
- Date
- 2024
- Source
- Nature communications 15: 55475547 (Journal)
- Registered Authors
- Luo, Lingfei
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Endothelial Cells*/cytology
- Endothelial Cells*/metabolism
- Lymphangiogenesis/physiology
- Lymphatic Vessels/cytology
- Lymphatic Vessels/metabolism
- Meninges*/cytology
- Meninges*/metabolism
- Regeneration/physiology
- Zebrafish*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 38956047 Full text @ Nat. Commun.
Citation
He, X., Xiong, D., Zhao, L., Fu, J., Luo, L. (2024) Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells. Nature communications. 15:55475547.
Abstract
The meninges are critical for the brain functions, but the diversity of meningeal cell types and intercellular interactions have yet to be thoroughly examined. Here we identify a population of meningeal lymphatic supporting cells (mLSCs) in the zebrafish leptomeninges, which are specifically labeled by ependymin. Morphologically, mLSCs form membranous structures that enwrap the majority of leptomeningeal blood vessels and all the mural lymphatic endothelial cells (muLECs). Based on its unique cellular morphologies and transcriptional profile, mLSC is characterized as a unique cell type different from all the currently known meningeal cell types. Because of the formation of supportive structures and production of pro-lymphangiogenic factors, mLSCs not only promote muLEC development and maintain the dispersed distributions of muLECs in the leptomeninges, but also are required for muLEC regeneration after ablation. This study characterizes a newly identified cell type in leptomeninges, mLSC, which is required for muLEC development, maintenance, and regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping