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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-130425-1
Luo, Lingfei
Email: lluo@swu.edu.cn
URL:
Affiliation: Lingfei Luo Lab
Address: Laboratory of Molecular Developmental Biology School of Life Sciences, Southwest University 2 Tiansheng Road, Beibei 400715 Chongqing China
Country: China
Phone: +86-23-68367957
Fax: +86-23-68367958
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
We are interested in the organogenesis and regeneration of digestive organs in particular liver and pancreas.


PUBLICATIONS
Chen, J., He, J., Ni, R., Yang, Q., Zhang, Y., Luo, L. (2019) Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish. Developmental Cell. 49(5):697-710.e5
Cao, Z., Mao, X., Luo, L. (2019) Germline Stem Cells Drive Ovary Regeneration in Zebrafish. Cell Reports. 26:1709-1717.e3
Yi, X., Yu, J., Ma, C., Dong, G., Shi, W., Li, H., Li, L., Luo, L., Sampath, K., Ruan, H., Huang, H. (2019) The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish. PLoS Genetics. 15:e1007408
Zhong, Y., Huang, W., Du, J., Wang, Z., He, J., Luo, L. (2018) Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and β cell development and regeneration in zebrafish. The Journal of biological chemistry. 294(3):932-940
Wang, Z., Song, J., Luo, L., Ma, J. (2018) Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Biochemical and Biophysical Research Communications. 505(2):378-384
Zou, Q., Gang, K., Yang, Q., Liu, X., Tang, X., Lu, H., He, J., Luo, L. (2018) The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish. The Journal of biological chemistry. 293(31):11971-11983
Yi, X., Yu, J., Ma, C., Li, L., Luo, L., Li, H., Ruan, H., Huang, H. (2018) Yap1/Taz are essential for the liver development in zebrafish. Biochemical and Biophysical Research Communications. 503(1):131-137
Ni, R., Luo, L. (2018) A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development. FEBS Open Bio. 8:722-731
Gao, C., Zhu, Z., Gao, Y., Lo, L.J., Chen, J., Luo, L., Peng, J. (2018) Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes. Journal of genetics and genomics = Yi chuan xue bao. 45:173-175
Cai, P., Mao, X., Zhao, J., Luo, L. (2018) Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochemical and Biophysical Research Communications. 497(2):776-782
He, J., Yang, Y., Zhang, J., Chen, J., Wei, X., He, J., Luo, L. (2017) Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(12):567-576
Tian, Y., Xu, J., Feng, S., He, S., Zhao, S., Zhu, L., Jin, W., Dai, Y., Luo, L., Qu, J.Y., Wen, Z. (2017) The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. The Journal of experimental medicine. 214(11):3347-3360
Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158
Wang, H., Luo, L., Yang, D. (2017) Loss of Gspt1l disturbs the patterning of the brain central arteries in zebrafish. Biochemical and Biophysical Research Communications. 486(1):156-162
Du, J., Yang, Q., Luo, L., Yang, D. (2017) C1qr and C1qrl redundantly regulate angiogenesis in zebrafish through controlling endothelial Cdh5. Biochemical and Biophysical Research Communications. 483(1):482-487
Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853
Chen, J., He, J., Li, L., Yang, D., Luo, L. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports. 6:26608
Liu, C., Wu, C., Yang, Q., Gao, J., Li, L., Yang, D., Luo, L. (2016) Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction. Immunity. 44(5):1162-76
Cao, Z., Wang, H., Mao, X., Luo, L. (2016) Noncanonical function of Threonyl-tRNA synthetase regulates Vascular Development in Zebrafish. Biochemical and Biophysical Research Communications. 473(1):67-72
Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62
Jiang, F., Chen, J., Ma, X., Huang, C., Zhu, S., Wang, F., Li, L., Luo, L., Ruan, H., Huang, H. (2015) Analysis of mutants from a genetic screening reveals the control of intestine and liver development by many common genes in zebrafish. Biochemical and Biophysical Research Communications. 460(3):838-44
Shi, W., Fang, Z., Li, L., Luo, L. (2015) Using zebrafish as the model organism to understand organ regeneration. Science China. Life sciences. 58:343-51
Shi, Y., Zhang, Y., Zhao, F., Ruan, H., Huang, H., Luo, L., Li, L. (2014) Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish. Scientific Reports. 4:5602
He, J., Lu, H., Zou, Q., and Luo, L. (2014) Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish. Gastroenterology. 146(3):789-800.e8
Li, L., and Luo, L.F. (2013) Zebrafish as the model system to study organogenesis and regeneration. Yi chuan = Hereditas. 35(4):421-432
Lu, H., Ma, J., Yang, Y., Shi, W., and Luo, L. (2013) EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development. Developmental Cell. 24(5):543-553
Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Retinoic acid signaling sequentially controls visceral and heart laterality in Zebrafish. The Journal of biological chemistry. 286(32):28533-43
Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Geminin is required for left-right patterning through regulating Kupffer's vesicle formation and ciliogenesis in zebrafish. Biochemical and Biophysical Research Communications. 410(2):164-9
Liu, X., Huang, S., Ma, J., Li, C., Zhang, Y., and Luo, L. (2009) NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. The Journal of cell biology. 184(6):805-815

NON-ZEBRAFISH PUBLICATIONS
Huiqiang Lu, Jun Ma, Yun Yang, Wenchao Shi, Lingfei Luo*. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev. Cell 24(5), 543-553.

Zhuan Li, Yu Lan, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Guangzhou Zhang, Liping Yang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang, Bing Liu*. (2012). Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell 11(5), 663-675.

Sizhou Huang, Jun Ma, Xiaolin Liu, Yaoguang Zhang, Lingfei Luo*. (2011). Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish. J. Biol. Chem. 286(32), 28533-28543.

Sizhou Huang, Jun Ma, Xiaolin Liu, Yaoguang Zhang, Lingfei Luo*. (2011). Geminin is required for left-right patterning through regulating Kupffer’s vesicle formation and ciliogenesis in zebrafish. Biochem. Biophys. Res. Commun. 410(2), 164-169.

Xiaolin Liu, Sizhou Huang, Jun Ma, Chun Li, Yaoguang Zhang, Lingfei Luo*. (2009). NF-κB and Snail1a coordinate the cell cycle with gastrulation. J. Cell Biol. 184(6), 805-815.

Lingfei Luo*, Yvonne Uerlings, Naisana S. Asli, Nicole Happel, Hendrik Knoetgen, Michael Kessel. (2007). Regulation of geminin functions by cell cycle dependent nuclear-cytoplasmic shuttling. Mol. Cell. Biol. 27(13), 4737-4744.

Mara Pitulescu, Michael Kessel, Lingfei Luo*. (2005). The regulation of embryonic patterning and DNA replication by geminin. Cell. Mol. Life Sci. 62(13), 1425-1433.

Lingfei Luo, Michael Kessel*. (2004). Geminin coordinates cell cycle and developmental control. Cell Cycle 3(6), 711-714.

Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen, Michael Kessel*. (2004). The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427(6976), 749-753.