PUBLICATION
Fipronil Affects Craniofacial and Heart Development in Zebrafish Embryos (Danio rerio)
- Authors
- Cooper, K.L., Krut, Z.G., Franz, B.D., Walker, B.S., Kramer, A.G., Morgan, J.R., Lassiter, C.S.
- ID
- ZDB-PUB-240416-2
- Date
- 2024
- Source
- Zebrafish 21: 181190181-190 (Journal)
- Registered Authors
- Lassiter, Christopher S.
- Keywords
- cardiac, craniofacial, fipronil, zebrafish
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian
- Humans
- Insecticides*/toxicity
- Pyrazoles/toxicity
- Water Pollutants, Chemical*
- Zebrafish
- PubMed
- 38621218 Full text @ Zebrafish
Citation
Cooper, K.L., Krut, Z.G., Franz, B.D., Walker, B.S., Kramer, A.G., Morgan, J.R., Lassiter, C.S. (2024) Fipronil Affects Craniofacial and Heart Development in Zebrafish Embryos (Danio rerio). Zebrafish. 21:181190181-190.
Abstract
Fipronil is a broad-spectrum insecticide that has off-target effects in developing vertebrate embryos. In this study, we investigate treatment of zebrafish embryos with fipronil over the course of 5 days and examine the effects on body length, the cardiovascular system, and craniofacial morphology. We found the insecticide caused shorter body length and a decrease in eye size. By examining specific heart chamber morphology, as well as jaw angle and length, we quantified defects including enlargement of the heart and increases in jaw length and width. Further studies are needed to assess the mechanisms of fipronil's effect on vertebrate development for both environmental and human health concerns.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping