PUBLICATION
Development, circuitry, and function of the zebrafish cerebellum
- Authors
- Pose-Méndez, S., Schramm, P., Valishetti, K., Köster, R.W.
- ID
- ZDB-PUB-230726-36
- Date
- 2023
- Source
- Cellular and molecular life sciences : CMLS 80: 227227 (Review)
- Registered Authors
- Köster, Reinhard W.
- Keywords
- Cerebellar circuitry, Cerebellar development, Cerebellum, Evolution, Granule cell, Purkinje cell, Zebrafish
- MeSH Terms
-
- Animals
- Brain
- Cell Count
- Cerebellum*
- Mammals
- Zebrafish*
- PubMed
- 37490159 Full text @ Cell. Mol. Life Sci.
Citation
Pose-Méndez, S., Schramm, P., Valishetti, K., Köster, R.W. (2023) Development, circuitry, and function of the zebrafish cerebellum. Cellular and molecular life sciences : CMLS. 80:227227.
Abstract
The cerebellum represents a brain compartment that first appeared in gnathostomes (jawed vertebrates). Besides the addition of cell numbers, its development, cytoarchitecture, circuitry, physiology, and function have been highly conserved throughout avian and mammalian species. While cerebellar research in avian and mammals is extensive, systematic investigations on this brain compartment in zebrafish as a teleostian model organism started only about two decades ago, but has provided considerable insight into cerebellar development, physiology, and function since then. Zebrafish are genetically tractable with nearly transparent small-sized embryos, in which cerebellar development occurs within a few days. Therefore, genetic investigations accompanied with non-invasive high-resolution in vivo time-lapse imaging represents a powerful combination for interrogating the behavior and function of cerebellar cells in their complex native environment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping