PUBLICATION
Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity
- Authors
- Wang, Y., Wang, H.M., Zhou, Y., Hu, L.H., Wan, J.M., Yang, J.H., Niu, H.B., Hong, X.P., Hu, P., Chen, L.B.
- ID
- ZDB-PUB-221125-3
- Date
- 2023
- Source
- Zoological research 44: 126141126-141 (Journal)
- Registered Authors
- Chen, Liangbiao
- Keywords
- Ectothermal, MAPK, Mitochondrial fission, Redox homeostasis, Thermal stress, Zebrafish
- MeSH Terms
-
- Animals
- Dual Specificity Phosphatase 1/genetics
- Gills
- Homeostasis
- Humans
- Mitochondria*
- Reactive Oxygen Species
- Zebrafish*/genetics
- PubMed
- 36419379 Full text @ Zool Res
Citation
Wang, Y., Wang, H.M., Zhou, Y., Hu, L.H., Wan, J.M., Yang, J.H., Niu, H.B., Hong, X.P., Hu, P., Chen, L.B. (2023) Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity. Zoological research. 44:126141126-141.
Abstract
Temperature tolerance restricts the distribution of a species. However, the molecular and cellular mechanisms that set the thermal tolerance limits of an organism are poorly understood. Here, we report on the function of dual-specificity phosphatase 1 (DUSP1) in thermal tolerance regulation. Notably, we found that dusp1-/- zebrafish grew normally but survived within a narrowed temperature range. The higher susceptibility of these mutant fish to both cold and heat challenges was attributed to accelerated cell death caused by aggravated mitochondrial dysfunction and over-production of reactive oxygen species in the gills. The DUSP1-MAPK-DRP1 axis was identified as a key pathway regulating these processes in both fish and human cells. These observations suggest that DUSP1 may play a role in maintaining mitochondrial integrity and redox homeostasis. We therefore propose that maintenance of cellular redox homeostasis may be a key mechanism for coping with cellular thermal stress and that the interplay between signaling pathways regulating redox homeostasis in the most thermosensitive tissue (i.e., gills) may play an important role in setting the thermal tolerance limit of zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping