PUBLICATION

Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models

Authors
Giaquinto, D., De Felice, E., Attanasio, C., Palladino, A., Schiano, V., Mollo, E., Lucini, C., de Girolamo, P., D'Angelo, L.
ID
ZDB-PUB-220413-15
Date
2022
Source
International Journal of Molecular Sciences   23(7): (Journal)
Registered Authors
Keywords
African turquoise killifish, aging, brain, gut, neuropeptides, zebrafish
MeSH Terms
  • Animals
  • Cyprinodontiformes*
  • Aging
  • Zebrafish
  • Neuropeptide Y
  • Brain
  • Neuropeptides*
(all 7)
PubMed
35409198 Full text @ Int. J. Mol. Sci.
Abstract
NPY is among the most abundant neuropeptides in vertebrate brain and is primarily involved in the regulation of food intake. The NPY system is also associated with the aging process showing beneficial effects on neuronal survival via autophagy modulation. Here, we explore the age-related regulation of NPY in the brain and foregut of the shortest- and longest-lived fish species, Nothobranchius furzeri and Danio rerio, respectively. These two research models, despite some similarities, display profound biological differences making them attractive vertebrates to elucidate the mechanisms underlying the regulation of neuropeptide synthesis and function. It is noteworthy that in both fish species only Npya has been identified, while in the other teleosts two classes of NPY (Npya and Npyb) have been annotated. Our findings document that in both species: (i) NPY is centrally regulated; (ii) NPY levels increase in the brain during aging; (iii) NPY is localized in the enteroendocrine cells as well as in the myenteric plexus and drastically decreases in old animals. According to our data, the age-related regulation in the gut resembles that described in other vertebrate species while the increased levels in the brain offer the unique possibility to explore the role of NPY in model organisms to develop future experimental and translatable approaches.
Genes / Markers
Figures
Figure Gallery (4 images)
Show all Figures
Expression
No data available
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
No data available
Antibodies
Name Type Antigen Genes Isotypes Host Organism
Ab4-npypolyclonal
    		IgGRabbit
    1 - 1 of 1
    Show
    Orthology
    No data available
    Engineered Foreign Genes
    No data available
    Mapping
    No data available
    Your Input Welcome
    We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
    Citation
    Giaquinto, D., De Felice, E., Attanasio, C., Palladino, A., Schiano, V., Mollo, E., Lucini, C., de Girolamo, P., D'Angelo, L. (2022) Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models. International Journal of Molecular Sciences. 23(7):.