PUBLICATION

Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses

Authors
Chang, W., Pedroni, A., Köster, R.W., Giacomello, S., Ampatzis, K.
ID
ZDB-PUB-210918-6
Date
2021
Source
Scientific Reports   11: 18408 (Journal)
Registered Authors
Köster, Reinhard W.
Keywords
none
MeSH Terms
  • Zebrafish/physiology*
  • Fluorescent Antibody Technique
  • Animals
  • Biomarkers
  • Electrophysiological Phenomena
  • Genes, Reporter
  • Purkinje Cells/cytology*
  • Purkinje Cells/metabolism
  • Immunohistochemistry
  • Animals, Genetically Modified
  • Cerebellum/cytology*
  • Cerebellum/metabolism
  • Cerebellum/physiology*
  • Gene Expression
(all 14)
PubMed
34526620 Full text @ Sci. Rep.
Abstract
Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. Compared with the Purkinje cells in the corpus cerebelli, the valvular Purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. Together, our findings expand further the regional functional differences of the Purkinje cell population and expose their non-locomotor functionality.
Genes / Markers
Figures
Figure Gallery (4 images)
Show all Figures
Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
bz13TgTransgenic Insertion
    1 - 1 of 1
    Show
    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    No data available
    Antibodies
    Name Type Antigen Genes Isotypes Host Organism
    Ab1-aldocmonoclonalMouse
    Ab1-GABApolyclonal
      		Rabbit
      Ab3-pvalbmonoclonal
        		IgG1Mouse
        1 - 3 of 3
        Show
        Orthology
        No data available
        Engineered Foreign Genes
        Marker Marker Type Name
        GFPEFGGFP
        1 - 1 of 1
        Show
        Mapping
        No data available
        Your Input Welcome
        We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
        Citation
        Chang, W., Pedroni, A., Köster, R.W., Giacomello, S., Ampatzis, K. (2021) Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses. Scientific Reports. 11:18408.