PUBLICATION

Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection

Authors
Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T.
ID
ZDB-PUB-210316-10
Date
2021
Source
Frontiers in Physiology   12: 626080 (Journal)
Registered Authors
Baxendale, Sarah, Cheung, King Yee, Jesuthasan, Suresh, Whitfield, Tanya T.
Keywords
Lifeact, actin, actin-rich projection, olfactory epithelium, olfactory placode, olfactory rod cell, zebrafish
MeSH Terms
none
PubMed
33716772 Full text @ Front. Physiol.
Abstract
We report the presence of a rare cell type, the olfactory rod cell, in the developing zebrafish olfactory epithelium. These cells each bear a single actin-rich rod-like apical projection extending 5-10 μm from the epithelial surface. Live imaging with a ubiquitous Lifeact-RFP label indicates that the olfactory rods can oscillate. Olfactory rods arise within a few hours of the olfactory pit opening, increase in numbers and size during larval stages, and can develop in the absence of olfactory cilia. Olfactory rod cells differ in morphology from the known classes of olfactory sensory neuron, but express reporters driven by neuronal promoters. A sub-population of olfactory rod cells expresses a Lifeact-mRFPruby transgene driven by the sox10 promoter. Mosaic expression of this transgene reveals that olfactory rod cells have rounded cell bodies located apically in the olfactory epithelium and have no detectable axon. We offer speculation on the possible function of these cells in the Discussion.
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