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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-607
Whitfield, Tanya T.
Email: t.whitfield@sheffield.ac.uk
URL: http://https://www.sheffield.ac.uk/bms/research/whitfield
Affiliation: Whitfield Lab
Address: Professor of Developmental Biology Bateson Centre Department of Biomedical Science University of Sheffield SHEFFIELD S10 2TN UK
Country: United Kingdom
Phone: 44-114-222-2350
Fax: +44 114 222 2787
Orcid ID: 0000-0003-1575-1504


BIOGRAPHY AND RESEARCH INTERESTS
Development of the zebrafish inner ear and lateral line. Please see my web page for details.


PUBLICATIONS
Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., O'Reilly, M., Derudas, M., Cantillon, D.M., Goodyear, R.J., Secker, A., Baxendale, S., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI insight. 2(24)
Alsina, B., Whitfield, T.T. (2017) Sculpting the labyrinth: morphogenesis of the developing inner ear. Seminars in cell & developmental biology. 65:47-59
Baxendale, S., Whitfield, T.T. (2016) Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course. Methods in cell biology. 134:165-209
Stooke-Vaughan, G.A., Obholzer, N.D., Baxendale, S., Megason, S.G., Whitfield, T.T. (2015) Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Development (Cambridge, England). 142(6):1137-45
Maier, E.C., Whitfield, T.T. (2014) RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities. PLoS Genetics. 10:e1004858
Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
Whitfield, T.T. (2013) Shedding new light on the origins of olfactory neurons. eLIFE. 2:e00648
Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012) The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (Cambridge, England). 139(10):1777-1787
Buck, L.M., Winter, M.J., Redfern, W.S., and Whitfield, T.T. (2012) Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research. 284(1-2):67-81
Hammond, K.L., and Whitfield, T.T. (2011) Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle. Development (Cambridge, England). 138:3977-3987
Abbas, L., Hajihashemi, S., Stead, L.F., Cooper, G.J., Ware, T.L., Munsey, T.S., Whitfield, T.T., and White, S.J. (2011) Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1. The Journal of physiology. 589(Pt 6):1489-503
Hammond, K.L., van Eeden, F.J., and Whitfield, T.T. (2010) Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development (Cambridge, England). 137(8):1361-1371
Hammond, K.L., and Whitfield, T.T. (2009) Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning. Gene expression patterns : GEP. 9(6):391-396
Abbas, L., and Whitfield, T.T. (2009) Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development (Cambridge, England). 136(16):2837-2848
Dutton, K., Abbas, L., Spencer, J., Brannon, C., Mowbray, C., Nikaido, M., Kelsh, R.N., and Whitfield, T.T. (2009) A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Disease models & mechanisms. 2(1-2):68-83
Hammond, K.L., Loynes, H.E., Mowbray, C., Runke, G., Hammerschmidt, M., Mullins, M.C., Hildreth, V., Chaudhry, B., and Whitfield, T.T. (2009) A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 4(2):e4368
Hammond, K.L., Baxendale, S., McCauley, D.W., Ingham, P.W., and Whitfield, T.T. (2009) Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evolution & development. 11(1):27-40
Whitfield, T.T., and Hammond, K.L. (2007) Axial patterning in the developing vertebrate inner ear. The International journal of developmental biology. 51(6-7):507-520
Hammond, K.L., and Whitfield, T.T. (2006) The developing lamprey ear closely resembles the zebrafish otic vesicle: otx1 expression can account for all major patterning differences. Development (Cambridge, England). 133(7):1347-1357
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M. (2005) Models of congenital deafness: Mouse and zebrafish. Drug discovery today. 2(2):85-92
Whitfield, T.T. (2005) Lateral line: precocious phenotypes and planar polarity. Current biology : CB. 15(2):R67-70
Kozlowski, D.J., Whitfield, T.T., Hukriede, N.A., Lam, W.K., and Weinberg, E.S. (2005) The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Developmental Biology. 277(1):27-41
Hammond, K.L., Loynes, H.E., Folarin, A.A., Smith, J., and Whitfield, T.T. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development (Cambridge, England). 130(7):1403-1417
Whitfield, T.T. (2002) Zebrafish as a model for hearing and deafness. Journal of neurobiology. 53(2):157-171
Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B. (2002) Development of the zebrafish inner ear. Developmental dynamics : an official publication of the American Association of Anatomists. 223(4):427-458
Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D. (2002) Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds. Mechanisms of Development. 112(1-2):183-189
Mowbray, C., Hammerschmidt, M., and Whitfield, T.T. (2001) Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line. Mechanisms of Development. 108(1-2):179-184
Whitfield-T. (1999) The New Fish Cook Books: The Zebrafish: Biology (Methods in Cell Biology, Vol. 59), The Zebrafish: Genetics and Genomics (Methods in Cell Biology, Vol. 60) edited by H. William Detrich, III, Monte Westerfield and Leonard I. Zon. Trends in cell biology. 9(11):464-465
Haddon, C., Mowbray, C., Whitfield, T., Jones, D., Gschmeissner, S., and Lewis, J. (1999) Hair cells without supporting cells: further studies in the ear of the zebrafish mind bomb mutant. Journal of neurocytology. 28(10-11):837-850
Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436
Whitfield, T., Haddon, C., and Lewis, J. (1997) Intercellular signals and cell-fate choices in the developing inner ear: origins of global and of fine-grained pattern. Seminars in cell & developmental biology. 8(3):239-247
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254

NON-ZEBRAFISH PUBLICATIONS
Whitfield, T. T., Heasman, J. and Wylie, C. C. (1995). Early embryonic expression of XLPOU-60, a Xenopus POU-domain protein. Developmental Biology 169, 759-769.

Whitfield, T. T., Sharpe, C. R. and Wylie. C. C. (1994). Nonsense-mediated mRNA decay in Xenopus oocytes and embryos. Developmental Biology 165, 731-734.

Whitfield, T., Heasman, J. and Wylie, C. (1993). XLPOU-60, a Xenopus POU-domain mRNA, is oocyte-specific from very early stages of oogenesis and localised to presumptive mesoderm and ectoderm in the blastula. Developmental Biology 155, 361-370.