PUBLICATION
Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
- Authors
- Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S.
- ID
- ZDB-PUB-190913-7
- Date
- 2019
- Source
- Nature communications 10: 4113 (Journal)
- Registered Authors
- Abdelilah-Seyfried, Salim, Heisenberg, Carl-Philipp, Herzog, Wiebke, Lecaudey, Virginie, Mochizuki, Naoki, Nakajima, Hiroyuki, Yelon, Deborah
- Keywords
- none
- MeSH Terms
-
- Animals
- Antigens, CD/metabolism
- Biomechanical Phenomena
- Cadherins/metabolism
- Cell Nucleus/metabolism
- Cell Proliferation
- Cell Size
- Cytoskeletal Proteins/metabolism
- Endocardium/cytology
- Endocardium/growth & development*
- Heart Atria/cytology
- Heart Atria/metabolism
- Homeobox Protein Nkx-2.5/metabolism
- Intercellular Junctions/metabolism
- Models, Biological
- Mutation/genetics
- Myocardium/metabolism*
- Signal Transduction*
- Trans-Activators/metabolism
- Wnt Proteins/metabolism
- Zebrafish/embryology*
- Zebrafish Proteins/metabolism
- PubMed
- 31511517 Full text @ Nat. Commun.
Citation
Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113.
Abstract
Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping