PUBLICATION

Zebrafish and medaka as models for biomedical research of bone diseases

Authors
Lleras-Forero, L., Winkler, C., Schulte-Merker, S.
ID
ZDB-PUB-190724-15
Date
2019
Source
Developmental Biology   457(2): 191-205 (Review)
Registered Authors
Schulte-Merker, Stefan, Winkler, Christoph
Keywords
none
MeSH Terms
  • Animals
  • Biomedical Research
  • Bone Diseases/genetics*
  • Bone Diseases/physiopathology*
  • Disease Models, Animal
  • Genome/genetics
  • Oryzias/genetics*
  • Whole Genome Sequencing
  • Zebrafish/genetics*
PubMed
31325453 Full text @ Dev. Biol.
Abstract
The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes