PUBLICATION

Progressive neurogenesis defines lateralis somatotopy

Authors
Pujol-Martí, J., Baudoin, J.P., Faucherre, A., Kawakami, K., and Lopez-Schier, H.
ID
ZDB-PUB-100621-19
Date
2010
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   239(7): 1919-1930 (Journal)
Registered Authors
Faucherre, Adele, Kawakami, Koichi, Lopez-Schier, Hernan, Marti, Jesus Pujol
Keywords
somatotopy, lateral line, Gal4, sensory neurons, zebrafish
MeSH Terms
  • Ganglia, Sensory/cytology
  • Ganglia, Sensory/metabolism
  • Sensory Receptor Cells/cytology
  • Sensory Receptor Cells/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Animals
  • Animals, Genetically Modified
  • Neurogenesis/genetics
  • Neurogenesis/physiology*
(all 10)
PubMed
20549716 Full text @ Dev. Dyn.
Abstract
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
Genes / Markers
Figures
Figure Gallery (9 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
nkhgn39dEtTransgenic Insertion
nkhspGFF53AEtTransgenic Insertion
    nkuasgfp1aTgTransgenic Insertion
      rw0130aTgTransgenic Insertion
        s1006tEtTransgenic Insertion
          s1999tTgTransgenic Insertion
            zf106TgTransgenic Insertion
              1 - 7 of 7
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              Human Disease / Model
              No data available
              Sequence Targeting Reagents
              No data available
              Fish
              Fish
              cntnap2ankhgn39dEt
              cntnap2ankhgn39dEt; rw0130aTg
              nkhspGFF53AEt
              nkhspGFF53AEt; nkuasgfp1aTg
              nkhspGFF53AEt; nkuasgfp1aTg; rw0130aTg
              rw0130aTg
              s1006tEt
              s1006tEt; s1999tTg
              zf106Tg
              1 - 9 of 9
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              Antibodies
              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              EGFPEFGEGFP
              GAL4EFGGAL4
              KaedeEFGKaede
              1 - 3 of 3
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              Mapping
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              Citation
              Pujol-Martí, J., Baudoin, J.P., Faucherre, A., Kawakami, K., and Lopez-Schier, H. (2010) Progressive neurogenesis defines lateralis somatotopy. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):1919-1930.