ZFIN ID: ZDB-PUB-100621-19
Progressive neurogenesis defines lateralis somatotopy
Pujol-Martí, J., Baudoin, J.P., Faucherre, A., Kawakami, K., and Lopez-Schier, H.
Date: 2010
Source: Developmental dynamics : an official publication of the American Association of Anatomists   239(7): 1919-1930 (Journal)
Registered Authors: Faucherre, Adele, Kawakami, Koichi, Lopez-Schier, Hernan, Marti, Jesus Pujol
Keywords: somatotopy, lateral line, Gal4, sensory neurons, zebrafish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Ganglia, Sensory/cytology
  • Ganglia, Sensory/metabolism
  • Neurogenesis/genetics
  • Neurogenesis/physiology*
  • Sensory Receptor Cells/cytology
  • Sensory Receptor Cells/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed: 20549716 Full text @ Dev. Dyn.
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.