PUBLICATION

Redundant Roles for Sox7 and Sox18 in Arteriovenous Specification in Zebrafish

Authors
Herpers, R., van de Kamp, E., Duckers, H.J., and Schulte-Merker, S.
ID
ZDB-PUB-071125-30
Date
2008
Source
Circulation research   102(1): 12-15 (Journal)
Registered Authors
Herpers, Robert, Schulte-Merker, Stefan
Keywords
zebrafish, sox7, sox18, AV-differentiation, hypotrichosis–lymphedema–telangiectasia, hereditary hemorrhagic telangiectasia
MeSH Terms
  • Animals
  • Aorta/growth & development
  • Arteries/abnormalities
  • Arteries/embryology
  • Arteries/growth & development
  • Blood Vessels/abnormalities
  • Blood Vessels/embryology
  • Blood Vessels/growth & development*
  • DNA-Binding Proteins/analysis
  • DNA-Binding Proteins/physiology
  • Embryonic Induction*
  • High Mobility Group Proteins/analysis
  • High Mobility Group Proteins/physiology*
  • SOXF Transcription Factors
  • Transcription Factors/analysis
  • Transcription Factors/physiology
  • Veins/abnormalities
  • Veins/embryology
  • Veins/growth & development
  • Zebrafish
  • Zebrafish Proteins/physiology
PubMed
18032732 Full text @ Circ. Res.
Abstract
The specification of arteries and veins is an essential process in establishing and maintaining a functional blood vessel system. Incorrect arteriovenous specification disrupts embryonic development but has also been diagnosed in human syndromes such as hypotrichosis-lymphedema-telangiectasia, characterized by defects in blood and lymphatic vessels and associated with mutations in SOX18. Here we characterize the role of sox7 and sox18 during zebrafish vasculogenesis. Sox7 and sox18 are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta which instead expresses venous markers, followed by dramatic arteriovenous shunt formations. Our study identifies members of the Sox family as key factors in specifying arteriovenous identity and will help to better understand Hypotrichosis-lymphedema-telangiectasia and other diseases.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes