PUBLICATION

Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia

Authors
Tucker, B., Hepperle, C., Kortschak, D., Rainbird, B., Wells, S., Oates, A.C., and Lardelli, M.
ID
ZDB-PUB-061108-22
Date
2007
Source
Gene expression patterns : GEP   7(3): 258-265 (Journal)
Registered Authors
Hepperle, Christine, Kortschak, Daniel, Oates, Andrew, Tucker, Ben
Keywords
Zebrafish, Epiboly, Cell migration, G protein-coupled receptor, Somitogenesis, Delta/Notch, Gene expression, Veins, Vasculature, Embryogenesis, Angiotensin receptor
MeSH Terms
  • Molecular Sequence Data
  • Cleavage Stage, Ovum/metabolism
  • Gene Expression Regulation, Developmental*
  • Amino Acid Sequence
  • Mesoderm/metabolism
  • Humans
  • In Situ Hybridization
  • Embryo, Nonmammalian/metabolism
  • Sequence Alignment
  • Blood Vessels/embryology
  • Blood Vessels/metabolism
  • Animals
  • Cloning, Molecular
  • Phylogeny
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Epithelium/embryology*
  • Epithelium/metabolism
  • Blastula/metabolism
  • Receptor, Angiotensin, Type 1/genetics*
  • Zebrafish Proteins/genetics*
  • Somites/cytology
  • Somites/metabolism
  • Gastrula/metabolism
(all 25)
PubMed
17085078 Full text @ Gene Expr. Patterns
Abstract
The human gene AGTRL1 is an angiotensin II receptor-like gene expressed in vasculature, which acts as the receptor for the small peptide APELIN, and a co-receptor for Human Immunodeficiency Virus. Mammalian AGTRL1 has been shown to modulate cardiac contractility, venous and arterial dilation, and endothelial cell migration in vitro, but no role in the development of the vasculature, or other tissues, has been described. We report the identification and expression of the zebrafish ortholog of the human gene AGTRL1. Zebrafish agtrl1a is first expressed before epiboly in dorsal precursors. During epiboly it is expressed in the enveloping layer, yolk syncytial layer and migrating mesendoderm. During segmentation stages, expression is observed in epithelial structures such as adaxial cells, border cells of the newly formed somites, developing lens, otic vesicles and venous vasculature.
Genes / Markers
Figures
Figure Gallery (3 images)
Show all Figures
Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
sox32_unspecified
    		Unspecified
    tbx16_unspecified
      		Unspecified
      tdgf1_unspecified
        		Unspecified
        te314a
          		Point Mutation
          tm98
            		Point Mutation
            tp37
              		Point Mutation
              tr233
                		Point Mutation
                1 - 7 of 7
                Show
                Human Disease / Model
                No data available
                Sequence Targeting Reagents
                No data available
                Fish
                Fish
                dlctm98/tm98
                dldtr233/tr233
                notch1atp37/tp37
                sox32unspecified
                tbx6te314a/te314a
                tbx16unspecified
                tdgf1unspecified
                tdgf1unspecified/unspecified
                WT
                1 - 9 of 9
                Show
                Antibodies
                No data available
                Orthology
                Gene Orthology
                aplnra
                aplnrb
                1 - 2 of 2
                Show
                Engineered Foreign Genes
                No data available
                Mapping
                No data available
                Your Input Welcome
                We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
                Citation
                Tucker, B., Hepperle, C., Kortschak, D., Rainbird, B., Wells, S., Oates, A.C., and Lardelli, M. (2007) Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene expression patterns : GEP. 7(3):258-265.