PUBLICATION

Genetic analysis of dopaminergic system development in zebrafish

Authors
Ryu, S., Holzschuh, J., Mahler, J., and Driever, W.
ID
ZDB-PUB-061020-17
Date
2006
Source
Journal of neural transmission. Supplementum   70: 61-66 (Journal)
Registered Authors
Driever, Wolfgang, Holzschuh, Jochen, Mahler, Julia, Ryu, Soojin
Keywords
none
MeSH Terms
  • Animals
  • Dopamine/genetics*
  • Dopamine/physiology*
  • Nervous System/growth & development*
  • Signal Transduction/genetics
  • Signal Transduction/physiology
  • Zebrafish/genetics*
  • Zebrafish/physiology*
PubMed
17017510 Full text @ J. Neural Transm. Suppl.
Abstract
Zebrafish have become an important model organism to study the genetic control of vertebrate nervous system development. Here, we present an overview on the formation of dopaminergic neuronal groups in zebrafish and compare the positions of DA neurons in fish and mammals using the neuromere model of the vertebrate brain. Based on mutant analysis, we evaluate the role of several signaling pathways in catecholaminergic neuron specification. We further discuss the prospect of identifying novel genes involved in dopaminergic development through forward genetics mutagenesis screens.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping