PUBLICATION
Genetic analysis of dopaminergic system development in zebrafish
- Authors
- Ryu, S., Holzschuh, J., Mahler, J., and Driever, W.
- ID
- ZDB-PUB-061020-17
- Date
- 2006
- Source
- Journal of neural transmission. Supplementum 70: 61-66 (Journal)
- Registered Authors
- Driever, Wolfgang, Holzschuh, Jochen, Mahler, Julia, Ryu, Soojin
- Keywords
- none
- MeSH Terms
-
- Animals
- Dopamine/genetics*
- Dopamine/physiology*
- Nervous System/growth & development*
- Signal Transduction/genetics
- Signal Transduction/physiology
- Zebrafish/genetics*
- Zebrafish/physiology*
- PubMed
- 17017510 Full text @ J. Neural Transm. Suppl.
Citation
Ryu, S., Holzschuh, J., Mahler, J., and Driever, W. (2006) Genetic analysis of dopaminergic system development in zebrafish. Journal of neural transmission. Supplementum. 70:61-66.
Abstract
Zebrafish have become an important model organism to study the genetic control of vertebrate nervous system development. Here, we present an overview on the formation of dopaminergic neuronal groups in zebrafish and compare the positions of DA neurons in fish and mammals using the neuromere model of the vertebrate brain. Based on mutant analysis, we evaluate the role of several signaling pathways in catecholaminergic neuron specification. We further discuss the prospect of identifying novel genes involved in dopaminergic development through forward genetics mutagenesis screens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping