PUBLICATION
Retinoic acid signaling restricts the cardiac progenitor pool
- Authors
- Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D.
- ID
- ZDB-PUB-050120-7
- Date
- 2005
- Source
- Science (New York, N.Y.) 307(5707): 247-249 (Journal)
- Registered Authors
- Begemann, Gerrit, Feldman, Jessica, Ingham, Philip, Keegan, Brian, Yelon, Deborah
- Keywords
- none
- MeSH Terms
-
- Aldehyde Oxidoreductases/genetics
- Aldehyde Oxidoreductases/metabolism
- Animals
- Blastomeres/cytology
- Blastomeres/physiology
- Blastula/cytology
- Blastula/physiology
- Cell Count
- Cell Differentiation
- Cell Proliferation
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/physiology
- Gastrula/physiology
- Heart/embryology*
- Mesoderm/cytology
- Myocytes, Cardiac/cytology
- Myocytes, Cardiac/physiology*
- Receptors, Retinoic Acid/antagonists & inhibitors
- Retinal Dehydrogenase
- Retinoids/pharmacology
- Signal Transduction*
- Stem Cells/cytology
- Stem Cells/physiology*
- Tretinoin/metabolism*
- Zebrafish
- PubMed
- 15653502 Full text @ Science
Citation
Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005) Retinoic acid signaling restricts the cardiac progenitor pool. Science (New York, N.Y.). 307(5707):247-249.
Abstract
Organogenesis begins with specification of a progenitor cell population, the size of which provides a foundation for the organ's final dimensions. Here, we present a new mechanism for regulating the number of progenitor cells by limiting their density within a competent region. We demonstrate that retinoic acid signaling restricts cardiac specification in the zebrafish embryo. Reduction of retinoic acid signaling causes formation of an excess of cardiomyocytes, via fate transformations that increase cardiac progenitor density within a multipotential zone. Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping