ZFIN ID: ZDB-PUB-050120-7
Retinoic acid signaling restricts the cardiac progenitor pool
Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D.
Date: 2005
Source: Science (New York, N.Y.)   307(5707): 247-249 (Journal)
Registered Authors: Begemann, Gerrit, Feldman, Jessica, Ingham, Philip, Keegan, Brian, Yelon, Deborah
Keywords: none
MeSH Terms:
  • Aldehyde Oxidoreductases/genetics
  • Aldehyde Oxidoreductases/metabolism
  • Animals
  • Blastomeres/cytology
  • Blastomeres/physiology
  • Blastula/cytology
  • Blastula/physiology
  • Cell Count
  • Cell Differentiation
  • Cell Proliferation
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/physiology
  • Gastrula/physiology
  • Heart/embryology*
  • Mesoderm/cytology
  • Myocytes, Cardiac/cytology
  • Myocytes, Cardiac/physiology*
  • Receptors, Retinoic Acid/antagonists & inhibitors
  • Retinal Dehydrogenase
  • Retinoids/pharmacology
  • Signal Transduction*
  • Stem Cells/cytology
  • Stem Cells/physiology*
  • Tretinoin/metabolism*
  • Zebrafish
PubMed: 15653502 Full text @ Science
Organogenesis begins with specification of a progenitor cell population, the size of which provides a foundation for the organ's final dimensions. Here, we present a new mechanism for regulating the number of progenitor cells by limiting their density within a competent region. We demonstrate that retinoic acid signaling restricts cardiac specification in the zebrafish embryo. Reduction of retinoic acid signaling causes formation of an excess of cardiomyocytes, via fate transformations that increase cardiac progenitor density within a multipotential zone. Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool.