PUBLICATION

Retinoic acid signaling restricts the cardiac progenitor pool

Authors
Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D.
ID
ZDB-PUB-050120-7
Date
2005
Source
Science (New York, N.Y.)   307(5707): 247-249 (Journal)
Registered Authors
Begemann, Gerrit, Feldman, Jessica, Ingham, Philip, Keegan, Brian, Yelon, Deborah
Keywords
none
MeSH Terms
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/physiology
  • Blastula/cytology
  • Blastula/physiology
  • Blastomeres/cytology
  • Blastomeres/physiology
  • Cell Differentiation
  • Heart/embryology*
  • Retinoids/pharmacology
  • Signal Transduction*
  • Receptors, Retinoic Acid/antagonists & inhibitors
  • Myocytes, Cardiac/cytology
  • Myocytes, Cardiac/physiology*
  • Zebrafish
  • Retinal Dehydrogenase
  • Aldehyde Oxidoreductases/genetics
  • Aldehyde Oxidoreductases/metabolism
  • Animals
  • Cell Count
  • Gastrula/physiology
  • Stem Cells/cytology
  • Stem Cells/physiology*
  • Mesoderm/cytology
  • Tretinoin/metabolism*
  • Cell Proliferation
(all 25)
PubMed
15653502 Full text @ Science
Abstract
Organogenesis begins with specification of a progenitor cell population, the size of which provides a foundation for the organ's final dimensions. Here, we present a new mechanism for regulating the number of progenitor cells by limiting their density within a competent region. We demonstrate that retinoic acid signaling restricts cardiac specification in the zebrafish embryo. Reduction of retinoic acid signaling causes formation of an excess of cardiomyocytes, via fate transformations that increase cardiac progenitor density within a multipotential zone. Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool.
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Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
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Mapping
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Citation
Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005) Retinoic acid signaling restricts the cardiac progenitor pool. Science (New York, N.Y.). 307(5707):247-249.