ZFIN ID: ZDB-PERS-960805-265
Ingham, Philip
Email: pingham@ntu.edu.sg
URL:
Affiliation: Ingham Singapore Lab
Address: Lee Kong Chian School of Medicine Nanyang Technological University Experimental Medicine Building 59 Nanyang Drive Singapore 636921
Country:
Phone: 65 6586 9736
Fax: 65 6779 1117
Orcid ID: 0000-0001-8224-9958


BIOGRAPHY AND RESEARCH INTERESTS
1977 BA (Hons) in Genetics, Cambridge University U.K.
1981 D.Phil Developmental Genetics University of Sussex, UK
1981-2 Royal Society European Exchange Postdoctoral fellow, LGME, Strasbourg, France
1982-85 Post doctoral research assistant, Imperial Cancer Research Fund, Mill Hill, U.K.
1986 Research Scientist, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1986-94 Staff Scientist, Imperial Cancer Research Fund, Oxford, U.K.
1994-96 Principal Scientist, Imperial Cancer Research Fund, London, U.K.
1996-09 Professor of Developmental Genetics, University of Sheffield, U.K.
2009 - Deputy Director, Institute of Molecular & Cell Biology, Singapore
2014 - Toh Kian Chui Distinguished Professor, LKC School of Medicine, Singapore

My early research focused on the genetic analysis of development in Drosophila. I identified and characterised the trithorax and super sex combs loci, applied the technique of in situ hybridisation to the analysis of the gap and pair rule gene hierarchy, cloned the patched and smoothened genes and elucidated their role, together with that of ci, fused and cos-2, in the Hh signal transduction pathway. Since the early 1990s my lab has used similar approaches in the analysis of zebrafish development. In 1993 we idenitifed three members of the Hh family (In collaboration with Andy McMahon and Cliff Tabin) - a major focus of our subsequent research has been the deployment of Hh signalling in muscle cell type specification. Current interests include the differentiaition and regeneration of skeletal muscle, as well as the evolution of signalling pathways and transcritpional control networks.


PUBLICATIONS
Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4
Ojeda Naharros, I., Cristian, F.B., Zang, J., Gesemann, M., Ingham, P.W., Neuhauss, S.C.F., Bachmann-Gagescu, R. (2018) Publisher Correction: The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance. Scientific Reports. 8:12534
Naharros, I.O., Cristian, F.B., Zang, J., Gesemann, M., Ingham, P.W., Neuhauss, S.C.F., Bachmann-Gagescu, R. (2018) The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance. Scientific Reports. 8:2211
Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000
Ahmed, M.U., Maurya, A.K., Cheng, L., Jorge, E.C., Schubert, F.R., Maire, P., Basson, M.A., Ingham, P.W., Dietrich, S. (2017) Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility. Developmental Biology. 430(1):90-104
Poon, K.L., Wang, X., Lee, S.G., Ng, A.S., Goh, W.H., Zhao, Z., Al-Haddawi, M., Wang, H., Mathavan, S., Ingham, P.W., Mcginnis, C., Carney, T.J. (2017) Transgenic Zebrafish Reporter Lines as Alternative in vivo Organ Toxicity Models. Toxicological sciences : an official journal of the Society of Toxicology. 156(1):133-148
Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
Lee, R.T., Ng, A.S., Ingham, P.W. (2016) Ribozyme Mediated gRNA Generation for In Vitro and In Vivo CRISPR/Cas9 Mutagenesis. PLoS One. 11:e0166020
Robertson, A.L., Ogryzko, N.V., Henry, K.M., Loynes, C.A., Foulkes, M.J., Meloni, M.M., Wang, X., Ford, C., Jackson, M., Ingham, P.W., Wilson, H.L., Farrow, S.N., Solari, R., Flower, R.J., Jones, S., Whyte, M.K., Renshaw, S.A. (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Disease models & mechanisms. 9(6):621-32
Zhao, Z., Lee, R.T., Pusapati, G.V., Iyu, A., Rohatgi, R., Ingham, P.W. (2016) An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO reports. 17(5):739-52
Leow, S.C., Poschmann, J., Too, P.G., Yin, J., Joseph, R., McFarlane, C., Dogra, S., Shabbir, A., Ingham, P.W., Prabhakar, S., Leow, M.K., Lee, Y.S., Ng, K.L., Chong, Y.S., Gluckman, P.D., Stünkel, W. (2016) The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Development (Cambridge, England). 143:950-61
Vaz, C., Wee, C.W., Lee, G.P., Ingham, P.W., Tanavde, V., Mathavan, S. (2015) Deep sequencing of small RNA facilitates tissue and sex associated microRNA discovery in zebrafish. BMC Genomics. 16:950
Ono, Y., Yu, W., Jackson, H.E., Parkin, C.A., Ingham, P.W. (2015) Adaxial cell migration in the zebrafish embryo is an active cell autonomous property that requires the Prdm1a transcription factor. Differentiation; research in biological diversity. 89(3-4):77-86
Jackson, H.E., Ono, Y., Wang, X., Elworthy, S., Cunliffe, V.T., Ingham, P.W. (2015) The role of Sox6 in zebrafish muscle fiber type specification. Skeletal muscle. 5:2
van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (Cambridge, England). 141(6):1228-1238
Burgon, J., Robertson, A.L., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L.R., Walker, P., Hoggett, E.E., Ward, J.R., Farrow, S.N., Zuercher, W.J., Jeffrey, P., Savage, C.O., Ingham, P.W., Hurlstone, A.F., Whyte, M.K., and Renshaw, S.A. (2014) Serum and Glucocorticoid-Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution. Journal of immunology (Baltimore, Md. : 1950). 192(4):1796-1805
Venkatesh, B., Lee, A.P., Ravi, V., Maurya, A.K., Lian, M.M., Swann, J.B., Ohta, Y., Flajnik, M.F., Sutoh, Y., Kasahara, M., Hoon, S., Gangu, V., Roy, S.W., Irimia, M., Korzh, V., Kondrychyn, I., Lim, Z.W., Tay, B.H., Tohari, S., Kong, K.W., Ho, S., Lorente-Galdos, B., Quilez, J., Marques-Bonet, T., Raney, B.J., Ingham, P.W., Tay, A., Hillier, L.W., Minx, P., Boehm, T., Wilson, R.K., Brenner, S., and Warren, W.C. (2014) Elephant shark genome provides unique insights into gnathostome evolution. Nature. 505(7482):174-179
Wang, X., Robertson, A.L., Li, J., Chai, R.J., Haishan, W., Sadiku, P., Ogryzko, N.V., Everett, M., Yoganathan, K., Luo, H.R., Renshaw, S.A., and Ingham, P.W. (2014) Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Disease models & mechanisms. 7(1):163-169
Wilkinson, R.N., Elworthy, S., Ingham, P.W., and van Eeden, F.J. (2013) A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies. Biotechniques. 55(6):314-316
Flinn, L.J., Keatinge, M., Bretaud, S., Mortiboys, H., Matsui, H., De Felice, E., Woodroof, H.I., Brown, L., McTighe, A., Soellner, R., Allen, C.E., Heath, P.R., Milo, M., Muqit, M.M., Reichert, A.S., Köster, R.W., Ingham, P.W., and Bandmann, O. (2013) TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Annals of neurology. 74(6):837-47
Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Siebold, C., and Rohatgi, R. (2013) Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. eLIFE. 2:e01340
Wang, X., Zhao, Z., Muller, J., Iyu, A., Khng, A.J., Guccione, E., Ruan, Y., and Ingham, P.W. (2013) Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biology Open. 2(11):1203-1213
Jackson, H.E., and Ingham, P.W. (2013) Control of muscle fibre-type diversity during embryonic development: The zebrafish paradigm. Mechanisms of Development. 130(9-10):447-57
Hewamadduma, C.A., Grierson, A.J., Ma, T.P., Pan, L., Moens, C.B., Ingham, P.W., Ramesh, T., and Shaw, P.J. (2013) Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish. Hum. Mol. Genet.. 22(12):2376-86
Maurya, A.K., Ben, J., Zhao, Z., Lee, R.T., Niah, W., Ng, A.S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F.J., and Ingham, P.W. (2013) Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genetics. 9(12):e1003955
Ingham, P.W. (2012) Zebrafish genetics gets the Scube on Hedgehog secretion. Genes and Development. 26(22):2468-2470
Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784
Wilkinson, R.N., Koudijs, M.J., Patient, R.K., Ingham, P.W., Schulte-Merker, S., and van Eeden, F.J. (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood. 120(2):477-488
Korzh, S., Winata, C.L., Zheng, W., Yang, S., Yin, A., Ingham, P., Korzh, V., and Gong, Z. (2011) The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology. 359(2):262-76
Seger, C., Hargrave, M., Wang, X., Chai, R.J., Elworthy, S., and Ingham, P.W. (2011) Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease. Developmental dynamics : an official publication of the American Association of Anatomists. 240(11):2440-51
Ben, J., Elworthy, S., Ng, A.S., van Eeden, F., and Ingham, P.W. (2011) Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (Cambridge, England). 138(22):4969-4978
Wang, X., Ono, Y., Tan, S.C., Chai, R.J., Parkin, C., and Ingham, P.W. (2011) Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo. Development (Cambridge, England). 138(20):4399-404
Bretaud, S., Macraild, S., Ingham, P.W., and Bandmann, O. (2011) The Influence of the Zebrafish Genetic Background on Parkinson's Disease-Related Aspects. Zebrafish. 8(3):103-8
Elks, P.M., van Eeden, F.J., Dixon, G., Wang, X., Reyes-Aldasoro, C.C., Ingham, P.W., Whyte, M.K., Walmsley, S.R., and Renshaw, S.A. (2011) Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model. Blood. 118(3):712-22
Maurya, A.K., Tan, H., Souren, M., Wang, X., Wittbrodt, J., and Ingham, P.W. (2011) Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Development (Cambridge, England). 138(4):755-765
Renshaw, S.A., and Ingham, P.W. (2010) Zebrafish models of the immune response: taking it on the ChIn. BMC Biology. 8(1):148
Kim, H.R., Richardson, J., van Eeden, F., and Ingham, P.W. (2010) Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish. BMC Biology. 8:65
Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
Loynes, C.A., Martin, J.S., Robertson, A., Trushell, D.M., Ingham, P.W., Whyte, M.K., and Renshaw, S.A. (2010) Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. Journal of Leukocyte Biology. 87(2):203-212
Lee, S.L., Rouhi, P., Jensen, L.D., Zhang, D., Ji, H., Hauptmann, G., Ingham, P., and Cao, Y. (2009) Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc. Natl. Acad. Sci. USA. 106(46):19485-19490
Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327
Flinn, L., Mortiboys, H., Volkmann, K., Köster, R.W., Ingham, P.W., and Bandmann, O. (2009) Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain : a journal of neurology. 132(Pt 6):1613-1623
Ingham, P.W. (2009) The power of the zebrafish for disease analysis. Hum. Mol. Genet.. 18(R1):R107-R112
Baxendale, S., Chen, C.K., Tang, H., Davison, C., Hateren, L.V., Croning, M.D., Humphray, S.J., Hubbard, S.J., and Ingham, P.W. (2009) Expression screening and annotation of a zebrafish myoblast cDNA library. Gene Expression Patterns. 9(2):73-82
Kim, H.R., and Ingham, P.W. (2009) The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryo. Developmental dynamics : an official publication of the American Association of Anatomists. 238(1):56-65
Hammond, K.L., Baxendale, S., McCauley, D.W., Ingham, P.W., and Whitfield, T.T. (2009) Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evolution & development. 11(1):27-40
Parkin, C.A., Allen, C.E., and Ingham, P.W. (2009) Hedgehog signalling is required for cloacal development in the zebrafish embryo. The International journal of developmental biology. 53(1):45-57
Flinn, L., Bretaud, S., Lo, C., Ingham, P.W., and Bandmann, O. (2008) Zebrafish as a new animal model for movement disorders. Journal of neurochemistry. 106(5):1991-1997
von Hofsten, J., Elworthy, S., Gilchrist, M.J., Smith, J.C., Wardle, F.C., and Ingham, P.W. (2008) Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO reports. 9(7):683-689
Elworthy, S., Hargrave, M., Knight, R., Mebus, K., and Ingham, P.W. (2008) Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity. Development (Cambridge, England). 135(12):2115-2126
Chico, T.J., Ingham, P.W., and Crossman, D.C. (2008) Modeling cardiovascular disease in the zebrafish. Trends in cardiovascular medicine. 18(4):150-155
Pagnon-Minot, A., Malbouyres, M., Haftek-Terreau, Z., Kim, H.R., Sasaki, T., Thisse, C., Thisse, B., Ingham, P.W., Ruggiero, F., and Le Guellec, D. (2008) Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. Developmental Biology. 316(1):21-35
Currie, P.D., Schilling, T.F., and Ingham, P.W. (2008) Small-scale marker-based screening for mutations in zebrafish development (2008). Meth. Mol. Biol.. 461:493-512
Renshaw, S.A., Loynes, C.A., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2007) Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Experimental Lung Research. 33(10):549-554
Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141
Moore, C.A., Parkin, C.A., Bidet, Y., and Ingham, P.W. (2007) A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Development (Cambridge, England). 134(17):3145-3153
Bretaud, S., Allen, C., Ingham, P.W., and Bandmann, O. (2007) p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease. Journal of neurochemistry. 100(6):1626-1635
Svetic, V., Hollway, G.E., Elworthy, S., Chipperfield, T.R., Davison, C., Adams, R.J., Eisen, J.S., Ingham, P.W., Currie, P.D., and Kelsh, R.N. (2007) Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants. Development (Cambridge, England). 134(5):1011-1022
Renshaw, S.A., Loynes, C.A., Trushell, D.M., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2006) A transgenic zebrafish model of neutrophilic inflammation. Blood. 108(13):3976-3978
Ingham, P.W., and Kim, H.R. (2005) Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo. Experimental cell research. 306(2):336-342
Tay, S.Y., Ingham, P.W., and Roy, S. (2005) A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development (Cambridge, England). 132(4):625-634
Keegan, B.R., Feldman, J.L., Begemann, G., Ingham, P.W., and Yelon, D. (2005) Retinoic acid signaling restricts the cardiac progenitor pool. Science (New York, N.Y.). 307(5707):247-249
Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes and Development. 18(13):1565-1576
Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Developmental Biology. 269(2):381-392
Baxendale, S., Davison, C., Muxworthy, C., Wolff, C., Ingham, P.W., and Roy, S. (2004) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nature Genetics. 36(1):88-93
Wolff, C., Roy, S., and Ingham, P.W. (2003) Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Current biology : CB. 13(14):1169-1181
Anderson, K.V. and Ingham, P.W. (2003) The transformation of the model organism: a decade of developmental genetics. Nature Genetics. (Suppl.) 33:285-293
Begemann, G., Gibert, Y., Meyer, A., and Ingham, P.W. (2002) Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development. Mechanisms of Development. 114(1-2):137
Ingham, P.W., and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes and Development. 15(23):3059-3087
Roy, S., Qiao, T., Wolff, C., and Ingham, P.W. (2001) Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Current biology : CB. 11(17):1358-1363
Begemann, G., Schilling, T.F., Rauch, G.J., Geisler, R., and Ingham, P.W. (2001) The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development (Cambridge, England). 128(16):3081-3094
Roy, S., Wolff, C., and Ingham, P.W. (2001) The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo. Genes and Development. 15(12):1563-1576
Schilling, T.F., Prince, V., and Ingham, P.W. (2001) Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Developmental Biology. 229:201-216
Norris, W., Neyt, C., Ingham, P.W., and Currie, P.D. (2000) Slow muscle induction by Hedgehog signalling in vitro. Journal of Cell Science. 113(Pt.15):2695-2703
Odenthal, J., van Eeden, F.J., Haffter, P., Ingham, P.W., and Nüsslein-Volhard, C. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Developmental Biology. 219(2):350-363
Brown, L.A., Rodaway, A.R.F., Schilling, T.F., Jowett, T., Ingham, P.W., Patient, R.K., and Sharrocks, A.D. (2000) Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mechanisms of Development. 90(2):237-252
Begemann, G. and Ingham, P.W. (2000) Developmental regulation of Tbx5 in zebrafish embryogenesis. Mechanisms of Development. 90(2):299-304
Lewis, K.E., Currie, P.D., Roy, S., Schauerte, H., Haffter, P., and Ingham, P.W. (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Developmental Biology. 216(2):469-480
Schilling, T.F., Concordet, J.-P., and Ingham, P.W. (1999) Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Developmental Biology. 210(2):277-287
Lewis, K.E., Concordet, J.P., and Ingham, P.W. (1999) Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to hedgehog signalling. Developmental Biology. 208:14-29
Currie, P.D., Schilling, T.F., and Ingham, P.W. (1999) Small-scale marker-based screening for mutations in zebrafish development. Meth. Mol. Biol.. 97:441-460
Currie P.D. and Ingham P.W. (1998) The generation and interpretation of positional information within the vertebrate myotome. Mechanisms of Development. 73:3-21
Blagden, C.S., P.D. Currie, P.W. Ingham, and S.M. Hughes (1997) Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes and Development. 11(17):2163-2175
Chang, B.E., Blader, P., Fischer, N., Ingham, P.W., and Strähle, U. (1997) Axial (HNF3b) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. The EMBO journal. 16(13):3955-3964
Strähle, U., Jesuthasan, S., Blader, P., Garcia-Villalba, P., Hatta, K., and Ingham, P.W. (1997) one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube. Genes and function. 1:131-148
Ingham, P.W. (1997) Zebrafish genetics and its implications for understanding vertebrate development. Hum. Mol. Genet.. 6:1755-1760
Rauch, G.-J., Hammerschmidt, M., Blader, P., Schauerte, H.E., Strähle, U., Ingham, P.W., McMahon, A.P. and Haffter, P. (1997) WNT5 is required for tail formation in the zebrafish embryo. Cold Spring Harbor symposia on quantitative biology. 62:227-233
Strähle, U., Blader, P., and Ingham, P.W. (1996) Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos. The International journal of developmental biology. 40(5):929-940
Concordet, J.P., Lewis, K.E., Moore, J.W., Goodrich, L.V., Johnson, R.L., Scott, M.P., and Ingham, P.W. (1996) Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development (Cambridge, England). 122(9):2835-2846
Currie, P.D. and Ingham, P.W. (1996) Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature. 382(6590):452-455
Blader, P., Strähle, U., and Ingham, P.W. (1996) Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives. Development genes and evolution. 206(1):3-13
Concordet, J.P. and Ingham, P. (1994) Catch of the decade. Nature. 369(6475):19-20
Strähle, U., Blader, P., Adam, J., and Ingham, P.W. (1994) A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends in genetics : TIG. 10:75-76
Krauss, S., Concordet, J.P., and Ingham, P.W. (1993) A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell. 75(7):1431-1444
Strähle, U., Blader, P., Henrique, D., and Ingham, P.W. (1993) Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes and Development. 7:1436-1446
Stern, C.D. and Ingham, P.W. (1992) Gastrulation. Papers presented at a meeting of the British Society for Development Biology at the University of Sussex, 1992, Cambridge: Company of BiologistsApril. :212 p
Strähle, U. and Ingham, P.W. (1992) Flight of fancy or a major new school?. Current biology : CB. 2:135-138

NON-ZEBRAFISH PUBLICATIONS
Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW. (2004) Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.Mech Dev. 121(6):507-18

Needham AJ, Kibart M, Crossley H, Ingham PW, Foster SJ. (2004) Drosophila melanogaster as a model host for Staphylococcus aureus infection. Microbiology. 150:2347-55.

Thomas C, Ingham PW. (2003) Hedgehog Signaling in the Drosophila Eye and Head. An analysis of the effects of different patched trans-heterozygotes. Genetics 165:1915-28

Shivdasani AA, Ingham PW. (2003) Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis. Curr Biol. 13:2065-72

McMahon AP., Ingham PW, & Tabin C. (2003) Development Roles and Clinical Significance of Hedgehog signaling. Current Topics in Developmental Biology 5: 1-114

Glise, B. Jones, DL & Ingham, PW (2002) Modulation of Hedgehog target gene expression by Notch and Wingless during Drosophila wing development. Developmental Biology 248: 93-106

Ingham PW, McMahon AP. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes & Devl 15: 3059-87.

Ingham PW. (2001) Hedgehog signaling: a tale of two lipids. Science. 294:1879-81.

Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW.
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.Curr Biol. 2001 Apr 17;11(8):608-13.

Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM.Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.Curr Biol. 2000 Oct 19;10(20):1315-8.

Placzek M, Ingham PW. Developmental genetics in Sheffield: a meeting point for Hedgehog researchers. Int J Dev Biol. 2000;44(1 Spec No):65-72.

Cunliffe VT, Ingham PW. Switching on the notochord. Genes Dev. 1999 Jul 1;13(13):1643-6.

Lewis KE, Drossopoulou G, Paton IR, Morrice DR, Robertson KE, Burt DW, Ingham PW, Tickle C. Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development. 1999 Jun;126(11):2397-407.

Ingham PW. Boning up on Hedgehog's movements. Nature. 1998 Jul 2;394(6688):16-7.

Ingham PW. trithorax and the regulation of homeotic gene expression in Drosophila: a historical perspective. Int J Dev Biol. 1998;42(3 Spec No):423-9.

Ingham PW.Transducing Hedgehog: the story so far.EMBO J. 1998 Jul 1;17(13):3505-11.

Currie PD, Ingham PW.The generation and interpretation of positional information within the vertebrate myotome. Mech Dev. 1998 Apr;73(1):3-21.

Quirk J, van den Heuvel M, Henrique D, Marigo V, Jones TA, Tabin C, Ingham PW.The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.Cold Spring Harb Symp Quant Biol. 1997;62:217-26.

Ingham PW.The patched gene in development and cancer. Curr Opin Genet Dev. 1998 Feb;8(1):88-94.

Ingham PW. Has the quest for a Wnt receptor finally frizzled out?
Trends Genet. 1996 Oct;12(10):382-4.

Forbes AJ, Spradling AC, Ingham PW, Lin H.The role of segment polarity genes during early oogenesis in Drosophila.Development. 1996 Oct;122(10):3283-94.

Alexandre C, Jacinto A, Ingham PW.Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 1996 Aug 15;10(16):2003-13.

van den Heuvel M, Ingham PW.smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.Nature. 1996 Aug 8;382(6591):547-51.

Forbes AJ, Lin H, Ingham PW, Spradling AC.hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.Development. 1996 Apr;122(4):1125-35.

Ingham PW.Signalling by hedgehog family proteins in Drosophila and vertebrate development. Curr Opin Genet Dev. 1995 Aug;5(4):492-8.

Fietz MJ, Jacinto A, Taylor AM, Alexandre C, Ingham PW.Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.Curr Biol. 1995 Jun 1;5(6):643-50.

Concordet JP, Ingham P.Developmental biology. Patterning goes sonic.
Nature. 1995 May 25;375(6529):279-80.

Ingham PW, Fietz MJ.Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr Biol. 1995 Apr 1;5(4):432-40.

Ingham P.Signal transduction. Dorsal developments.Nature. 1994 Dec 8;372(6506):500-1.

Paroush Z, Finley RL Jr, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D.Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins.Cell. 1994 Dec 2;79(5):805-15.

Ingham PW. Pattern formation. Hedgehog points the way.Curr Biol. 1994 Apr 1;4(4):347-50. Review.

Fietz MJ, Concordet JP, Barbosa R, Johnson R, Krauss S, McMahon AP, Tabin C, Ingham PW.The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl. 1994;:43-51.

Ingham PW. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.Nature. 1993 Dec 9;366(6455):560-2.

Taylor AM, Nakano Y, Mohler J, Ingham PW.Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech Dev. 1993 Jul;42(1-2):89-96.

Ingham PW, Hidalgo A. Regulation of wingless transcription in the Drosophila embryo.Development. 1993 Jan;117(1):283-91.

Forbes AJ, Nakano Y, Taylor AM, Ingham PW. Genetic analysis of hedgehog signalling in the Drosophila embryo.Dev Suppl. 1993;:115-24.

Eisenberg LM, Ingham PW, Brown AM.Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less.Dev Biol. 1992 Nov;154(1):73-83.

Holland P, Ingham P, Krauss S.Development and evolution. Mice and flies head to head.Nature. 1992 Aug 20;358(6388):627-8.

Ingham PW, Martinez Arias A. Boundaries and fields in early embryos.
Cell. 1992 Jan 24;68(2):221-35.

Ingham PW, Taylor AM, Nakano Y. Role of the Drosophila patched gene in positional signalling.Nature. 1991 Sep 12;353(6340):184-7.

Ingham PW.Segment polarity genes and cell patterning within the Drosophila body segment.Curr Opin Genet Dev. 1991 Aug;1(2):261-7.

Hidalgo A, Ingham P.Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.Development. 1990 Sep;110(1):291-301.

Phillips RG, Roberts IJ, Ingham PW, Whittle JR. The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development. 1990 Sep;110(1):105-14.