PUBLICATION
Cloning and expression of the TALE superclass homeobox Meis2 gene during zebrafish embryonic development
- Authors
- Biemar, F., Devos, N., Martial, J.A., Driever, W., and Peers, B.
- ID
- ZDB-PUB-011214-10
- Date
- 2001
- Source
- Mechanisms of Development 109(2): 427-431 (Journal)
- Registered Authors
- Biemar, Frédéric, Devos, Nathalie, Driever, Wolfgang, Martial, Joseph A., Peers, Bernard
- Keywords
- homeobox, TALE, meis, zebrafish, development, segmental expression, salivary gland, C genes, Drosophila, homothorax, limb, differentiation, extradenticle, vertebrate PBX
- MeSH Terms
-
- Rhombencephalon/embryology
- Tissue Distribution
- Amino Acid Sequence
- Zebrafish Proteins*
- Genes, Homeobox
- Phylogeny
- Open Reading Frames
- Zebrafish
- Animals
- Base Sequence
- Central Nervous System/embryology
- In Situ Hybridization
- Time Factors
- Molecular Sequence Data
- Homeodomain Proteins/biosynthesis*
- Homeodomain Proteins/genetics*
- PubMed
- 11731263 Full text @ Mech. Dev.
Citation
Biemar, F., Devos, N., Martial, J.A., Driever, W., and Peers, B. (2001) Cloning and expression of the TALE superclass homeobox Meis2 gene during zebrafish embryonic development. Mechanisms of Development. 109(2):427-431.
Abstract
Meis and Prep/Pknox (MEINOX family) proteins, together with Pbx (PBC family) proteins, belong to the TALE superfamily characterized by an atypical homeodomain containing three additional amino acids between helix 1 and helix 2. Members of the MEINOX and PBC families have been isolated in Caenorhabditis elegans, Drosophila, Xenopus, chick, mouse and human, and play crucial roles in many aspects of embryogenesis. Here, we report the isolation of meis2 in zebrafish. Expression of meis2 is first detected at the beginning of gastrulation. Later during embryogenesis, meis2 transcripts are found in distinct domains of the central nervous system with the strongest expression in the hindbrain. Expression was also detected in the isthmus, along the spinal cord and in the lateral mesoderm. As development proceeds, meis2 is also expressed in the developing retina, pharyngeal arches, and in the vicinity of the gut tube.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping