PUBLICATION

A dual role for the zebrafish unplugged gene in motor axon pathfinding and pharyngeal development

Authors
Zhang, J., Malayaman, S., Davis, C., and Granato, M.
ID
ZDB-PUB-011119-1
Date
2001
Source
Developmental Biology   240(2): 560-573 (Journal)
Registered Authors
Granato, Michael
Keywords
spinal cord; motor axon; guidance; choice point; pathway selection; neural development; pharyngeal arch; hyoid; zebrafish
MeSH Terms
  • Homeodomain Proteins/genetics*
  • Growth Cones/ultrastructure
  • Animals
  • Zebrafish Proteins*
  • Axons/ultrastructure*
  • Gene Expression Regulation, Developmental
  • Alleles
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Branchial Region/abnormalities
  • Branchial Region/embryology*
  • Chromosome Mapping
  • Gene Deletion
  • Motor Neurons/ultrastructure*
  • Phenotype
(all 15)
PubMed
11784083 Full text @ Dev. Biol.
Abstract
On their way toward their synaptic targets, motor growth cones encounter multiple choice points, where they are confronted with trajectory choices. We have previously shown that the zebrafish unplugged gene acts as a somite-derived cue controlling pathway choice of primary motor axons. Here, we demonstrate that this trajectory choice is not exclusively controlled by a single unplugged-dependent process, but depends on the coordinated function of additional cues. We also show that secondary motor neurons, most similar to those in birds and mammals, depend on the unplugged gene to navigate a choice point, suggesting that primary and secondary motor neurons share common mechanisms controlling axonal path selection. Moreover, we show that the unplugged gene plays an additional role guiding secondary motor axons through a single segmental nerve. Finally, we report that unplugged larvae display a striking pharyngeal arch defect, consistent with a dual function of the unplugged gene in axonal guidance and cell motility.
Genes / Markers
Figures
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Expression
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Phenotype
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Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
No data available
Mapping