header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-678
Granato, Michael
Email: granatom@mail.med.upenn.edu
URL: http://www.med.upenn.edu/granato/index.shtml
Affiliation: Michael Granato Lab
Address: Department of Cell and Developmental Biology University of Pennsylvania 1210 Biomedical Research Building II 421 Curie Boulevard Philadelphia, PA 19104 USA
Country: United States
Phone: (215) 898-2745
Fax: (215) 898-9871
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Genetic control of axonal guidance and neural circuit formation in the zebrafish embryo:

Research in the lab focuses on two aspects of nervous system assembly. One set of projects focuses on how motor axons find their way to their muscle targets. In genetic screens we have identified several mutants in which motor axons go astray: instead of finding their correct targets, they get lost in the maze. Through the analysis of these mutants, we have identified a specialized group of cells producing multiple signals. Each of the signals is essential for motor axons to navigate particular portions of the maze. A central focus in the lab is now to understand the molecular mechanisms by which these signals direct axons.

A second set of projects focuses on neural circuits relevant to neuropsychiatric disease. To navigate their local environment, animals integrate a multitude of sensory information to appropriately modulate their motor behaviors. In vertebrates, a prominent motor behavior elicited by abrupt sensory stimuli, is the startle response. The startle response is mediated by neural architecture that appears conserved amongst vertebrates, including zebrafish and mammals. In humans, deficits in modulating the acoustic startle response are a feature of several complex genetic psychiatric disorders, including schizophrenia. The goal of our studies is to establish the zebrafish as a model system to study the genetic basis of acoustic startle response regulation and thereby to identify genetic lesions underlying abnormal motor control in psychiatric diseases.


PUBLICATIONS
Harvey, B.M., Baxter, M., Granato, M. (2019) Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting. PLoS One. 14:e0218667
Bremer, J., Marsden, K.C., Miller, A., Granato, M. (2019) The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology. 2:195
Randlett, O., Haesemeyer, M., Forkin, G., Shoenhard, H., Schier, A.F., Engert, F., Granato, M. (2019) Distributed Plasticity Drives Visual Habituation Learning in Larval Zebrafish. Current biology : CB. 29(8):1337-1345.e4
Ducommun Priest, M., Navarro, M.F., Bremer, J., Granato, M. (2019) Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. PLoS Genetics. 15:e1007982
Gribble, K.D., Walker, L.J., Saint-Amant, L., Kuwada, J.Y., Granato, M. (2018) The synaptic receptor Lrp4 promotes peripheral nerve regeneration. Nature communications. 9:2389
Marsden, K.C., Jain, R.A., Wolman, M.A., Echeverry, F.A., Nelson, J.C., Hayer, K.E., Miltenberg, B., Pereda, A.E., Granato, M. (2018) A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold. Cell Reports. 23:878-887
Jain, R.A., Wolman, M.A., Marsden, K.C., Nelson, J.C., Shoenhard, H., Echeverry, F.A., Szi, C., Bell, H., Skinner, J., Cobbs, E.N., Sawada, K., Zamora, A.D., Pereda, A.E., Granato, M. (2018) A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making. Current biology : CB. 28(9):1357-1369.e5
Bremer, J., Skinner, J., Granato, M. (2017) A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoS One. 12:e0178854
Miller, A.C., Whitebirch, A.C., Shah, A.N., Marsden, K.C., Granato, M., O'Brien, J., Moens, C.B. (2017) A genetic basis for molecular asymmetry at vertebrate electrical synapses. eLIFE. 6:e25364
Bremer, J., Granato, M. (2016) Myosin phosphatase Fine-tunes Zebrafish Motoneuron Position during Axonogenesis. PLoS Genetics. 12:e1006440
Remédio, L., Gribble, K.D., Lee, J.K., Kim, N., Hallock, P.T., Delestrée, N., Mentis, G.Z., Froemke, R.C., Granato, M., Burden, S.J. (2016) Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes & Development. 30:1058-69
Hoffman, E.J., Turner, K.J., Fernandez, J.M., Cifuentes, D., Ghosh, M., Ijaz, S., Jain, R.A., Kubo, F., Bill, B.R., Baier, H., Granato, M., Barresi, M.J., Wilson, S.W., Rihel, J., State, M.W., Giraldez, A.J. (2016) Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 89(4):725-33
Marsden, K.C., Granato, M. (2015) In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation. Cell Reports. 13:1733-40
Isaacman-Beck, J., Schneider, V., Franzini-Armstrong, C., Granato, M. (2015) The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration. Neuron. 88(4):691-703
Fischer, A., Wolman, M., Granato, M., Parsons, M., McCallion, A.S., Proescher, J., English, E. (2015) Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model. Neurotoxicology and teratology. 50:1-10
Butler, M.G., Iben, J.R., Marsden, K.C., Epstein, J.A., Granato, M., Weinstein, B.M. (2015) SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish. Development (Cambridge, England). 142(8):1542-52
Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. (2015) A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron. 85(6):1200-11
Banerjee, S., Hayer, K., Hogenesch, J.B., Granato, M. (2015) Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England). 142:753-62
Rosenberg, A.F., Isaacman-Beck, J., Franzini-Armstrong, C., Granato, M. (2014) Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:14668-81
Wolman, M.A., de Groh, E.D., McBride, S.M., Jongens, T.A., Granato, M., Epstein, J.A. (2014) Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1. Cell Reports. 8(5):1265-70
Jain, R.A., Bell, H., Lim, A., Chien, C.B., Granato, M. (2014) Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:2898-909
Hao, L.T., Duy, P.Q., Jontes, J.D., Wolman, M., Granato, M., and Beattie, C.E. (2013) Temporal requirement for SMN in motoneuron development. Human molecular genetics. 22(13):2612-25
Banerjee, S., Isaacman-Beck, J., Schneider, V.A., and Granato, M. (2013) A Novel Role for Lh3 Dependent ECM Modifications during Neural Crest Cell Migration in Zebrafish. PLoS One. 8(1):e54609
Sainath, R., and Granato, M. (2013) Plexin a3 and turnout regulate motor axonal branch morphogenesis in zebrafish. PLoS One. 8(1):e54071
Shin, J., Padmanabhan, A., de Groh, E.D., Lee, J.S., Haidar, S., Dahlberg, S., Guo, F., He, S., Wolman, M.A., Granato, M., Lawson, N.D., Wolfe, S.A., Kim, S.H., Solnica-Krezel, L., Kanki, J.P., Ligon, K.L., Epstein, J.A., and Look, A.T. (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease models & mechanisms. 5(6):881-894
Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P. (2012) Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Developmental Biology. 365(2):434-444
Hao, L.T., Wolman, M., Granato, M., and Beattie, C.E. (2012) Survival motor neuron affects plastin 3 protein levels leading to motor defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(15):5074-5084
Lakhina, V., Marcaccio, C.L., Shao, X., Lush, M.E., Jain, R.A., Fujimoto, E., Bonkowsky, J.L., Granato, M., and Raper, J.A. (2012) Netrin/DCC Signaling Guides Olfactory Sensory Axons to Their Correct Location in the Olfactory Bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(13):4440-4456
Rosenberg, A.F., Wolman, M.A., Franzini-Armstrong, C., and Granato, M. (2012) In vivo nerve-macrophage interactions following peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11):3989-3909
Gordon, L.R., Gribble, K.D., Syrett, C.M., and Granato, M. (2012) Initiation of synapse formation by Wnt-induced MuSK endocytosis. Development (Cambridge, England). 139(5):1023-1033
Wolman, M., and Granato, M. (2012) Behavioral genetics in larval zebrafish: Learning from the young. Developmental Neurobiology. 72(3):366-372
Gyda, M., Wolman, M., Lorent, K., and Granato, M. (2012) The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. PLoS Genetics. 8(11):e1003106
Wolman, M.A., Jain, R.A., Liss, L., and Granato, M. (2011) Chemical modulation of memory formation in larval zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(37):15468-73
Banerjee, S., Gordon, L., Donn, T.M., Berti, C., Moens, C.B., Burden, S.J., and Granato, M. (2011) A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development (Cambridge, England). 138(15):3287-3296
Jain, R.A., Wolman, M.A., Schmidt, L.A., Burgess, H.A., and Granato, M. (2011) Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance. PLoS One. 6(10):e26510
Burgess, H.A., Schoch, H., and Granato, M. (2010) Distinct Retinal Pathways Drive Spatial Orientation Behaviors in Zebrafish Navigation. Current biology : CB. 20(4):381-386
Jing, L., Gordon, L.R., Shtibin, E., and Granato, M. (2010) Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. PLoS One. 5(1):e8843
Burgess, H.A., Johnson, S.L., and Granato, M. (2009) Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish. Genes, brain, and behavior. 8(5):500-511
Facchin, L., Burgess, H.A., Siddiqi, M., Granato, M., and Halpern, M.E. (2009) Determining the function of zebrafish epithalamic asymmetry. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364(1519):1021-1032
Jing, L., Lefebvre, J.L., Gordon, L.R., and Granato, M. (2009) Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron. 61(5):721-733
Alvarez-Delfin, K., Morris, A.C., Snelson, C.D., Gamse, J.T., Gupta, T., Marlow, F.L., Mullins, M.C., Burgess, H.A., Granato, M., and Fadool, J.M. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proceedings of the National Academy of Sciences of the United States of America. 106(6):2023-2028
Burgess, H.A., and Granato, M. (2008) The neurogenetic frontier--lessons from misbehaving zebrafish. Briefings in functional genomics & proteomics. 7(6):474-482
Palaisa, K.A., and Granato, M. (2007) Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance. Development (Cambridge, England). 134(18):3251-3257
Burgess, H.A., and Granato, M. (2007) Modulation of locomotor activity in larval zebrafish during light adaptation. The Journal of experimental biology. 210(14):2526-2539
Burgess, H.A., and Granato, M. (2007) Sensorimotor gating in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(18):4984-4994
Lefebvre, J.L., Jing, L., Becaficco, S., Franzini-Armstrong, C., and Granato, M. (2007) Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proceedings of the National Academy of Sciences of the United States of America. 104(7):2483-2488
Chalasani, S.H., Sabol, A., Xu, H., Gyda, M.A., Rasband, K., Granato, M., Chien, C.B., and Raper, J.A. (2007) Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(5):973-980
Schneider, V.A., and Granato, M. (2007) Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2. Matrix biology : journal of the International Society for Matrix Biology. 26(1):12-19
Schneider, V.A., and Granato, M. (2006) The Myotomal diwanka (lh3) Glycosyltransferase and Type XVIII Collagen Are Critical for Motor Growth Cone Migration. Neuron. 50(5):683-695
Downes, G.B., and Granato, M. (2006) Supraspinal input is dispensable to generate glycine-mediated locomotive behaviors in the zebrafish embryo. Journal of neurobiology. 66(5):437-451
Schweitzer, J., Becker, T., Lefebvre, J., Granato, M., Schachner, M., and Becker, C.G. (2005) Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 234(3):550-566
Panzer, J.A., Gibbs, S.M., Dosch, R., Wagner, D., Mullins, M.C., Granato, M., and Balice-Gordon, R.J. (2005) Neuromuscular synaptogenesis in wild-type and mutant zebrafish. Developmental Biology. 285(2):340-357
Hirata, H., Saint-Amant, L., Downes, G.B., Cui, W.W., Zhou, W., Granato, M., and Kuwada, J.Y. (2005) Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor β-subunit. Proceedings of the National Academy of Sciences of the United States of America. 102(23):8345-8350
Birely, J., Schneider, V.A., Santana, E., Dosch, R., Wagner, D.S., Mullins, M.C., and Granato, M. (2005) Genetic screens for genes controlling motor nerve-muscle development and interactions. Developmental Biology. 280(1):162-176
Zhang, J., Lefebvre, J.L., Zhao, S., and Granato, M. (2004) Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice. Nature Neuroscience. 7(12):1303-1309
Hirata, H., Saint-Amant, L., Waterbury, J., Cui, W., Zhou, W., Li, Q., Goldman, D., Granato, M., and Kuwada, J.Y. (2004) accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development (Cambridge, England). 131(21):5457-5468
Downes, G.B., and Granato, M. (2004) Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental Biology. 270(1):232-245
Lefebvre, J.L., Ono, F., Puglielli, C., Seidner, G., Franzini-Armstrong, C., Brehm, P., and Granato, M. (2004) Increased neuromuscular activity causes axonal defects and muscular degeneration. Development (Cambridge, England). 131(11):2605-2618
Granato, M. (2003) On best behavior: cadherins drive slow muscle to their limits. Developmental Cell. 5:819-820
Zeller, J., Schneider, V., Malayaman, S., Higashijima, S., Okamoto, H., Gui, J., Lin, S., and Granato, M. (2002) Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues. Developmental Biology. 252(2):241-256
Downes, G.B., Waterbury, J.A., and Granato, M. (2002) Rapid in vivo labeling of identified zebrafish neurons. Genesis (New York, N.Y. : 2000). 34(3):196-202
Schneider, V., Zeller, J., and Granato, M. (2002) The zebrafish diwanka gene controls multiple aspects of motor axon migration. Developmental Biology. 247(2):497
Zhang, J., Zhao, S.X., and Granato, M. (2002) Genetic analysis of axonal guidance in the zebrafish embryo. Developmental Biology. 247(2):481
Beattie, C.E., Granato, M., and Kuwada, J.Y. (2002) Cellular, genetic and molecular mechanisms of axonal guidance in the zebrafish. Results and problems in cell differentiation. 40:252-269
Zhang, J., Malayaman, S., Davis, C., and Granato, M. (2001) A dual role for the zebrafish unplugged gene in motor axon pathfinding and pharyngeal development. Developmental Biology. 240(2):560-573
Lorent, K., Liu, K.S., Fetcho, J.R., and Granato, M. (2001) The zebrafish space cadet gene controls axonal pathfinding of neurons that modulate fast turning movements. Development (Cambridge, England). 128(11):2131-2142
Granato, M. (2001) Genetic control of neural circuit formation in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1072
Zhang, J. and Granato, M. (2000) The zebrafish unplugged gene controls motor axon pathway selection. Development (Cambridge, England). 127(10):2099-2111
Zeller, J. and Granato, M. (1999) The zebrafish diwanka gene controls an early step of motor growth cone migration. Development (Cambridge, England). 126(15):3461-3472
Brand, M. and Granato, M. (1999) Keeping and raising zebrafish. In Zebrafish: A Practical Approach, S. Schulte-Merker and C. Nüsslein-Volhard, eds. IRL Press.
van Eeden, F.J.M., Granato, M., Odenthal, J., and Haffter, P. (1999) Developmental mutant screens in the zebrafish. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:21-41
Nicolson, T., Rüsch, A., Friedrich, R.W., Granato, M., Ruppersberg, J.P., and Nüsslein-Volhard, C. (1998) Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron. 20:271-283
Rauch, G.-J., Granato, M., and Haffter, P. (1997) A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels. Tech. Tips Online T01208.
Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development (Cambridge, England). 123:179-190
Heisenberg, C.P., Brand, M., Jiang, Y.J., Warga, R.M., Beuchle, D., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development (Cambridge, England). 123:191-203
Jiang, Y.J., Brand, M., Heisenberg, C.P., Beuchle, D., Furutani-Seiki, M., Kelsh, R.N., Warga, R.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development (Cambridge, England). 123:205-216
Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239
Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262
Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356
Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389
Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R.N., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:391-398
Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450
Kane, D.A., Hammerschmidt, M., Mullins, M.C., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish epiboly mutants. Development (Cambridge, England). 123:47-55
Kane, D.A., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Heisenberg-, C.P., Jiang, Y.J., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish early arrest mutants. Development (Cambridge, England). 123:57-66
Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., and Nüsslein-Volhard, C. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England). 123:81-93
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., van Eeden, F.J., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development (Cambridge, England). 123:95-102
Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115
Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:143-151
Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276
Granato, M. and Nüsslein-Volhard, C. (1996) Fishing for genes controlling development. Current opinion in genetics & development. 6(4):461-468

NON-ZEBRAFISH PUBLICATIONS