ZFIN Morpholino: MO3-mmp2

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-mmp2

Expressed Gene	Anatomy	Figures
dbh	chromaffin cell	Fig. 7 from Chou et al., 2014
nr5a1a	interrenal gland interrenal primordium	Fig. 7 from Chou et al., 2014

Phenotype

Phenotype resulting from MO3-mmp2

Phenotype	Fish	Figures
adrenal gland development process quality, abnormal	WT + MO3-mmp2	Fig. 5 , Fig. 7 from Chou et al., 2014
interrenal angiogenic sprout decreased length, abnormal	s843Tg + MO3-mmp2	Fig. 5 from Chou et al., 2014
interrenal gland position, abnormal	s843Tg + MO3-mmp2	Fig. 5 from Chou et al., 2014
interrenal gland animal organ morphogenesis process quality, abnormal	WT + MO3-mmp2	Fig. 5 , Fig. 7 from Chou et al., 2014
interrenal gland epithelial to mesenchymal transition decreased occurrence, abnormal	zf346Tg + MO3-mmp2	Fig. 6 from Chou et al., 2014
lymph vessel development disrupted, abnormal	hu4453Tg + MO3-mmp2	Fig. 2 from Detry et al., 2012
thoracic duct hypoplastic, abnormal	hu4453Tg + MO3-mmp2	Fig. 2 from Detry et al., 2012
whole organism edematous, abnormal	y1Tg + MO3-mmp2	text only from Detry et al., 2012
whole organism viability, abnormal	hu4453Tg + MO3-mmp2	text only from Detry et al., 2012

Phenotype of all Fish created by or utilizing MO3-mmp2

Phenotype	Fish	Conditions	Figures
interrenal gland animal organ morphogenesis process quality, abnormal	WT + MO3-mmp2	standard conditions	Fig. 7 from Chou et al., 2014
adrenal gland development process quality, abnormal	WT + MO3-mmp2	standard conditions	Fig. 7 from Chou et al., 2014
whole organism edematous, abnormal	hu4453Tg + MO3-mmp2	standard conditions	text only from Detry et al., 2012
thoracic duct hypoplastic, abnormal	hu4453Tg + MO3-mmp2	standard conditions	Fig. 2 from Detry et al., 2012
lymph vessel development disrupted, abnormal	hu4453Tg + MO3-mmp2	standard conditions	Fig. 2 from Detry et al., 2012
whole organism viability, abnormal	hu4453Tg + MO3-mmp2	standard conditions	text only from Detry et al., 2012
interrenal gland position, abnormal	s843Tg + MO3-mmp2	standard conditions	Fig. 5 from Chou et al., 2014
interrenal gland animal organ morphogenesis process quality, abnormal	s843Tg + MO3-mmp2	standard conditions	Fig. 5 from Chou et al., 2014
adrenal gland development process quality, abnormal	s843Tg + MO3-mmp2	standard conditions	Fig. 5 from Chou et al., 2014
interrenal angiogenic sprout decreased length, abnormal	s843Tg + MO3-mmp2	standard conditions	Fig. 5 from Chou et al., 2014
whole organism edematous, abnormal	y1Tg + MO3-mmp2	standard conditions	text only from Detry et al., 2012
whole organism viability, abnormal	y1Tg + MO3-mmp2	standard conditions	text only from Detry et al., 2012
lymph vessel development disrupted, abnormal	y1Tg + MO3-mmp2	standard conditions	Fig. 2 from Detry et al., 2012
thoracic duct hypoplastic, abnormal	y1Tg + MO3-mmp2	standard conditions	Fig. 2 from Detry et al., 2012
interrenal gland epithelial to mesenchymal transition decreased occurrence, abnormal	zf346Tg + MO3-mmp2	standard conditions	Fig. 6 from Chou et al., 2014

Citations

Include unpublished citations

Chou, C.W., Zhuo, Y.L., Jiang, Z.Y., Liu, Y.W. (2014) The Hemodynamically-Regulated Vascular Microenvironment Promotes Migration of the Steroidogenic Tissue during Its Interaction with Chromaffin Cells in the Zebrafish Embryo. PLoS One. 9:e107997
Detry, B., Erpicum, C., Paupert, J., Blacher, S., Maillard, C., Bruyère, F., Pendeville, H., Remacle, T., Lambert, V., Balsat, C., Ormenese, S., Lamaye, F., Janssens, E., Moons, L., Cataldo, D., Kridelka, F., Carmeliet, P., Thiry, M., Foidart, J.M., Struman, I., and Noel, A. (2012) Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase. Blood. 119(21):5048-5056

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