ZFIN Morpholino: MO6-ackr3b

Target Location

Genome Build: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO6-ackr3b

No data available

Phenotype

Phenotype resulting from MO6-ackr3b

Phenotype	Fish	Figures
posterior lateral line neuromast decreased amount, abnormal	WT + MO6-ackr3b	Fig. 7 , text only from Dambly-Chaudière et al., 2007
posterior lateral line neuromast primordium migration disrupted, abnormal	zf106Tg + MO6-ackr3b	Fig. 7 , Fig. 9 from Dambly-Chaudière et al., 2007 Fig. 2 , Fig. 3 from Valentin et al., 2007
posterior lateral line primordium shape, abnormal	zf106Tg + MO6-ackr3b	Fig. 3 from Valentin et al., 2007
posterior lateral line primordium split, abnormal	zf106Tg + MO6-ackr3b	Fig. 3 from Valentin et al., 2007
posterior lateral line primordium anterior region snai1b expression increased amount, abnormal	zf106Tg + MO6-ackr3b	Fig. 2 from Neelathi et al., 2018

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Phenotype of all Fish created by or utilizing MO6-ackr3b

Phenotype	Fish	Conditions	Figures
posterior lateral line neuromast primordium migration disrupted, abnormal	WT + MO6-ackr3b	standard conditions	Fig. 7 , Fig. 9 from Dambly-Chaudière et al., 2007
posterior lateral line neuromast decreased amount, abnormal	WT + MO6-ackr3b	standard conditions	Fig. 7 , text only from Dambly-Chaudière et al., 2007
posterior lateral line neuromast primordium migration disrupted, abnormal	zf106Tg + MO6-ackr3b	standard conditions	Fig. 2 , Fig. 3 from Valentin et al., 2007
posterior lateral line primordium shape, abnormal	zf106Tg + MO6-ackr3b	standard conditions	Fig. 3 from Valentin et al., 2007
posterior lateral line primordium anterior region snai1b expression increased amount, abnormal	zf106Tg + MO6-ackr3b	standard conditions	Fig. 2 from Neelathi et al., 2018

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Citations

Include unpublished citations

Neelathi, U.M., Dalle Nogare, D., Chitnis, A.B. (2018) Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.. Development (Cambridge, England). 145(14):
Breau, M.A., Wilson, D., Wilkinson, D.G., and Xu, Q. (2012) Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium. Development (Cambridge, England). 139(12):2246-2253
Olesnicky Killian, E.C., Birkholz, D.A., and Artinger, K.B. (2009) A role for chemokine signaling in neural crest cell migration and craniofacial development. Developmental Biology. 333(1):161-172
Dambly-Chaudière, C., Cubedo, N., and Ghysen, A. (2007) Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Developmental Biology. 7:23
Valentin, G., Haas, P., and Gilmour, D. (2007) The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Current biology : CB. 17(12):1026-1031

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