Morpholino

MO1-ppargc1a

ID

ZDB-MRPHLNO-080505-1

Name

MO1-ppargc1a

Previous Names

MO1-ppargc1al

Target

ppargc1a (1)

Sequence

5' - CCTGATTACACCTGTCCCACGCCAT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ppargc1a

Expressed Gene	Anatomy	Figures
cimap1b	pronephros multi-ciliated epithelial cell	Fig. 2 , Fig. 3 , Fig. 4 from Chambers et al., 2020
myl7	myocardium	Fig. 1 from Chambers et al., 2020
slc12a3	pronephric distal late tubule	Fig. 2 , Fig. 3 from Chambers et al., 2018
trpm7	pronephric proximal straight tubule pronephros single ciliated epithelial cell	Fig. 2 from Chambers et al., 2020 Fig. 2 , Fig. 3 from Chambers et al., 2018

Phenotype

Phenotype resulting from MO1-ppargc1a

Phenotype	Fish	Figures
determination of heart left/right asymmetry decreased process quality, abnormal	TU + MO1-ppargc1a	Fig. 1 from Chambers et al., 2020
heart mislocalised, abnormal	TU + MO1-ppargc1a	Fig. 1 from Chambers et al., 2020
Kupffer's vesicle has fewer parts of type Kupffer's vesicle cilium, abnormal	TU + MO1-ppargc1a	Fig. 1 from Chambers et al., 2020
Kupffer's vesicle cilium decreased length, abnormal	TU + MO1-ppargc1a	Fig. 1 from Chambers et al., 2020
Kupffer's vesicle cilium assembly decreased process quality, abnormal	TU + MO1-ppargc1a	Fig. 1 from Chambers et al., 2020
pronephric distal late tubule slc12a3 expression decreased distribution, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2018
pronephric proximal straight tubule trpm7 expression increased distribution, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2018
pronephros has extra parts of type pronephros single ciliated epithelial cell, abnormal	TU + MO1-ppargc1a	Fig. 2 from Chambers et al., 2020
pronephros has fewer parts of type pronephros multi-ciliated epithelial cell, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 , Fig. 4 from Chambers et al., 2020
pronephros cilium ab1-tuba labeling decreased amount, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros cilium decreased length, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros cilium assembly decreased process quality, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros distal region has fewer parts of type ciliated epithelial cell ciliary basal body, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros proximal region has fewer parts of type ciliated epithelial cell ciliary basal body, abnormal	TU + MO1-ppargc1a	Fig. 2 , Fig. 3 from Chambers et al., 2020
trunk curved ventral, abnormal	TU + MO1-ppargc1a	Fig. 4 from Chambers et al., 2020

Phenotype of all Fish created by or utilizing MO1-ppargc1a

Phenotype	Fish	Conditions	Figures
pronephros has number of pronephros multi-ciliated epithelial cell, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
heart mislocalised, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 1 from Chambers et al., 2020
pronephros distal region has number of ciliated epithelial cell ciliary basal body, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
determination of heart left/right asymmetry decreased process quality, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 1 from Chambers et al., 2020
pronephros cilium assembly process quality, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
pronephric distal late tubule slc12a3 expression decreased distribution, abnormal	TU + MO1-ppargc1a	control	Fig. 2 , Fig. 3 from Chambers et al., 2018
pronephros has extra parts of type pronephros single ciliated epithelial cell, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 from Chambers et al., 2020
Kupffer's vesicle cilium assembly decreased process quality, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 1 from Chambers et al., 2020
trunk curved ventral, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 4 from Chambers et al., 2020
pronephros cilium decreased length, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros distal region has fewer parts of type ciliated epithelial cell ciliary basal body, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 from Chambers et al., 2020
Kupffer's vesicle has fewer parts of type Kupffer's vesicle cilium, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 1 from Chambers et al., 2020
pronephric proximal straight tubule trpm7 expression increased distribution, abnormal	TU + MO1-ppargc1a	control	Fig. 2 , Fig. 3 from Chambers et al., 2018
pronephros cilium ab1-tuba labeling amount, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
pronephros cilium length, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
pronephros cilium assembly decreased process quality, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 from Chambers et al., 2020
Kupffer's vesicle cilium decreased length, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 1 from Chambers et al., 2020
pronephros cilium ab1-tuba labeling decreased amount, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros proximal region has number of ciliated epithelial cell ciliary basal body, ameliorated	TU + MO1-ppargc1a	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 3 from Chambers et al., 2020
pronephros proximal region has fewer parts of type ciliated epithelial cell ciliary basal body, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 from Chambers et al., 2020
pronephros has fewer parts of type pronephros multi-ciliated epithelial cell, abnormal	TU + MO1-ppargc1a	standard conditions	Fig. 2 , Fig. 3 , Fig. 4 from Chambers et al., 2020
muscle morphology, abnormal	WT + MO1-ppargc1a + MO2-ppargc1a	standard conditions	Fig. 9 from Hanai et al., 2007
skeletal muscle tissue development disrupted, abnormal	WT + MO1-ppargc1a + MO2-ppargc1a	standard conditions	Fig. 9 from Hanai et al., 2007
myotome skeletal muscle cell morphology, abnormal	WT + MO1-ppargc1a + MO2-ppargc1a	standard conditions	Fig. 9 from Hanai et al., 2007
trunk curvature, ameliorated	TU + MO1-ppargc1a + MO1-ptgs1	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 4 from Chambers et al., 2020
trunk curved ventral, exacerbated	TU + MO1-ppargc1a + MO1-ptgs1	standard conditions	Fig. 4 from Chambers et al., 2020
pronephros cilium assembly process quality, ameliorated	TU + MO1-ppargc1a + MO1-ptgs1	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 4 from Chambers et al., 2020
pronephros has fewer parts of type ciliated epithelial cell ciliary basal body, exacerbated	TU + MO1-ppargc1a + MO1-ptgs1	standard conditions	Fig. 4 from Chambers et al., 2020
pronephros cilium assembly decreased process quality, exacerbated	TU + MO1-ppargc1a + MO1-ptgs1	standard conditions	Fig. 4 from Chambers et al., 2020
pronephros cilium decreased length, exacerbated	TU + MO1-ppargc1a + MO1-ptgs1	standard conditions	Fig. 4 from Chambers et al., 2020
pronephros cilium length, ameliorated	TU + MO1-ppargc1a + MO1-ptgs1	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 4 from Chambers et al., 2020
pronephros has number of pronephros multi-ciliated epithelial cell, ameliorated	TU + MO1-ppargc1a + MO1-ptgs1	chemical treatment by environment: 16,16-dimethylprostaglandin E2	Fig. 4 from Chambers et al., 2020

Citations