Gene
ppargc1a
- ID
- ZDB-GENE-080505-1
- Name
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
- Symbol
- ppargc1a Nomenclature History
- Previous Names
-
- PGC1 (1)
- ppargc1al
- gb:dq017637
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have nuclear receptor transcription coactivator activity and transcription factor binding activity. Involved in late distal convoluted tubule development; proximal straight tubule development; and skeletal muscle tissue development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017637 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | PGC-1 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z0A6
|
884 | ||||
|
UniProtKB:A0A8M6Z7F8
|
885 | ||||
|
UniProtKB:A0A8M1REN0
|
873 | ||||
|
UniProtKB:A0A8M6Z1V5
|
872 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-ppargc1a | polyclonal | Rabbit |
|
Abcam plc
|
4 |
Plasmids
No data available