Gene

ppargc1a

ID

ZDB-GENE-080505-1

Name

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Symbol

ppargc1a Nomenclature History

Previous Names

PGC1 (1)
ppargc1al
gb:dq017637

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have nuclear receptor transcription coactivator activity and transcription factor binding activity. Involved in late distal convoluted tubule development; proximal straight tubule development; and skeletal muscle tissue development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

37 figures from 27 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

dq017637 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppargc1a Human Ortholog

No data available

Associated With ppargc1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Family	IPR034605	PGC-1
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	PGC-1	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:A0A8M6Z0A6 InterPro	884
UniProtKB:A0A8M6Z7F8 InterPro	885
UniProtKB:A0A8M1REN0 InterPro	873
UniProtKB:A0A8M6Z1V5 InterPro	872

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ppargc1a-201 (1) Ensembl	Ensembl		2,580 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-ppargc1a	polyclonal	ppargc1a		Rabbit	IHC WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations