ZFIN Morpholino: MO2-myd88

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-myd88

No data available

Phenotype

Phenotype resulting from MO2-myd88

Phenotype	Fish	Figures
activation of innate immune response decreased process quality, abnormal	WT + MO2-myd88	Fig. 6 from van der Vaart et al., 2013
alkaline phosphatase activity decreased occurrence, abnormal	WT + MO2-myd88	Fig. 1 from Bates et al., 2007
intestinal bulb peptide hormone secreting cell decreased amount, abnormal	WT + MO2-myd88	Fig. 4 from Troll et al., 2018
posterior intestine goblet cell decreased amount, abnormal	WT + MO2-myd88	Fig. 3, Fig. 4 from Troll et al., 2018
whole organism myd88 expression decreased amount, abnormal	WT + MO2-myd88	Fig. 8 from Fehr et al., 2016

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Phenotype of all Fish created by or utilizing MO2-myd88

Phenotype	Fish	Conditions	Figures
fourth ventricle monocyte decreased amount, abnormal	AB + MO2-myd88	bacterial treatment by injection: Pseudomonas aeruginosa	Fig. 1 from Cambier et al., 2017
fourth ventricle monocyte decreased amount, abnormal	AB + MO2-myd88	bacterial treatment by injection: Staphylococcus aureus	Fig. 1 from Cambier et al., 2017
fourth ventricle monocyte chemotaxis decreased occurrence, abnormal	AB + MO2-myd88	bacterial treatment by injection: Staphylococcus aureus	Fig. 1 from Cambier et al., 2017
fourth ventricle neutrophil decreased amount, abnormal	AB + MO2-myd88	bacterial treatment by injection: Staphylococcus aureus	Fig. 1 from Cambier et al., 2017
fourth ventricle neutrophil decreased amount, abnormal	AB + MO2-myd88	bacterial treatment by injection: Pseudomonas aeruginosa	Fig. 1 from Cambier et al., 2017

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Citations

Include unpublished citations

Peña, O.A., Lubin, A., Hockings, C., Rowell, J., Jung, Y., Hoade, Y., Dace, P.E.I., Valdivia, L.E., Tuschl, K., Boiers, C., Virgilio, M., Richardson, S.E., Payne, E.M. (2021) TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling. Blood advances. 5(20):4112-4124
Cafora, M., Brix, A., Forti, F., Loberto, N., Aureli, M., Briani, F., Pistocchi, A. (2020) Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 20(6):1046-1052
Cambier, C.J., Banik, S.M., Buonomo, J.A., Bertozzi, C.R. (2020) Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity. eLIFE. 9:
Yang, L., Jiménez, J.A., Earley, A.M., Hamlin, V., Kwon, V., Dixon, C.T., Shiau, C.E. (2020) Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration. eLIFE. 9:
Rosowski, E.E., Raffa, N., Knox, B.P., Golenberg, N., Keller, N.P., Huttenlocher, A. (2018) Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. PLoS pathogens. 14:e1007229
Troll, J.V., Hamilton, M.K., Abel, M.L., Ganz, J., Bates, J.M., Stephens, W.Z., Melancon, E., van der Vaart, M., Meijer, A.H., Distel, M., Eisen, J.S., Guillemin, K. (2018) Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development (Cambridge, England). 145(4)
Cambier, C.J., O'Leary, S.M., O'Sullivan, M.P., Keane, J., Ramakrishnan, L. (2017) Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages. Immunity. 47(3):552-565.e4
Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 170:973-985.e10
Mesureur, J., Feliciano, J.R., Wagner, N., Gomes, M.C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A.H., Vergunst, A.C. (2017) Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens. 13:e1006437
Fehr, A.G., Ruetten, M., Seth-Smith, H.M., Nufer, L., Voegtlin, A., Lehner, A., Greub, G., Crosier, P.S., Neuhauss, S.C., Vaughan, L. (2016) A Zebrafish Model for Chlamydia Infection with the Obligate Intracellular Pathogen Waddlia chondrophila.. Frontiers in microbiology. 7:1829

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