ZFIN Morpholino: MO1-six7

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-six7

Expressed Gene	Anatomy	Figures
egr2b	hindbrain	Fig. 1 from Inbal et al., 2007
emx3	forebrain	Fig. 1 from Inbal et al., 2007
gsc	prechordal plate	Fig. S4 from Inbal et al., 2007
kctd12.1	habenula	Fig. 1 from Inbal et al., 2007
lft1	epithalamus lateral plate mesoderm notochord prechordal plate (all 4)	Fig. 2 , Fig. 3 , Fig. 5 , Fig. S4 from Inbal et al., 2007

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Phenotype

Phenotype resulting from MO1-six7

Phenotype	Fish	Figures
embryonic retina morphogenesis in camera-type eye disrupted, abnormal	q16aTg; q16bTg + MO1-six7	Fig. 8 from Saade et al., 2013
retinal ganglion cell layer apoptotic process increased occurrence, abnormal	WT + MO1-six7	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal inner nuclear layer apoptotic process increased occurrence, abnormal	WT + MO1-six7	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal outer nuclear layer cell population proliferation temporally extended, abnormal	WT + MO1-six7	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal outer nuclear layer retinal rod cell increased amount, abnormal	q16aTg; q16bTg + MO1-six7	Fig. 8 from Saade et al., 2013

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Phenotype of all Fish created by or utilizing MO1-six7

Phenotype	Fish	Conditions	Figures
retinal rod cell increased amount, abnormal	WT + MO1-six7	standard conditions	Fig. 2 , Fig. 3 from Sotolongo-Lopez et al., 2016
retinal ganglion cell layer apoptotic process increased occurrence, abnormal	WT + MO1-six7	standard conditions	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal inner nuclear layer apoptotic process increased occurrence, abnormal	WT + MO1-six7	standard conditions	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal rod cell cell population proliferation increased occurrence, abnormal	WT + MO1-six7	standard conditions	Fig. 3 from Sotolongo-Lopez et al., 2016
retinal outer nuclear layer cell population proliferation temporally extended, abnormal	WT + MO1-six7	standard conditions	Fig. 3 from Sotolongo-Lopez et al., 2016

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Citations

Include unpublished citations

Sotolongo-Lopez, M., Alvarez-Delfin, K., Saade, C.J., Vera, D.L., Fadool, J.M. (2016) Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish. PLoS Genetics. 12:e1005968
Saade, C.J., Alvarez-Delfin, K., and Fadool, J.M. (2013) Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(5):1804-1814
Carlin, D., Sepich, D., Grover, V.K., Cooper, M.K., Solnica-Krezel, L., and Inbal, A. (2012) Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling. Development (Cambridge, England). 139(14):2614-2624
Geng, X., Speirs, C., Lagutin, O., Inbal, A., Liu, W., Solnica-Krezel, L., Jeong, Y., Epstein, D.J., and Oliver, G. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Developmental Cell. 15(2):236-247
Inbal, A., Kim, S.H., Shin, J., and Solnica-Krezel, L. (2007) Six3 represses nodal activity to establish early brain asymmetry in zebrafish. Neuron. 55(3):407-415

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