ZFIN Morpholino: MO1-mdm2

Target Location

Genome Build: GRCz11Chromosome: 4

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-mdm2

Expressed Gene	Anatomy	Figures
cdkn1a	whole organism	Fig. 8 from Robu et al., 2007
tp53	whole organism	Fig. 7 from Tao et al., 2013 Fig. 9 from Robu et al., 2007

1 - 2 of 2

Phenotype

Phenotype resulting from MO1-mdm2

Phenotype	Fish	Figures
apoptotic process increased occurrence, abnormal	WT + MO1-mdm2	Fig. 2 from Tao et al., 2013
head decreased size, abnormal	WT + MO1-mdm2	Fig. 1 from Robu et al., 2007
nervous system apoptotic, abnormal	WT + MO1-mdm2	Fig. 1 , Fig. 2 from Robu et al., 2007

1 - 3 of 3

Phenotype of all Fish created by or utilizing MO1-mdm2

Phenotype	Fish	Conditions	Figures
head decreased size, abnormal	WT + MO1-mdm2	standard conditions	Fig. 1 from Robu et al., 2007
apoptotic process increased occurrence, abnormal	WT + MO1-mdm2	standard conditions	Fig. 2 from Tao et al., 2013
nervous system apoptotic, abnormal	WT + MO1-mdm2	standard conditions	Fig. 1 , Fig. 2 from Robu et al., 2007
podocyte ab1-nphs1 labeling decreased amount, abnormal	mitfa^w2/w2; mpv17^a9/a9; li1Tg + MO1-mdm2 + MO3-mdm2	standard conditions	Fig. 2 from Thomasova et al., 2015
podocyte ab1-nphs1 labeling decreased distribution, abnormal	mitfa^w2/w2; mpv17^a9/a9; li1Tg + MO1-mdm2 + MO3-mdm2	standard conditions	Fig. 2 from Thomasova et al., 2015

1 - 5 of 7 Show all

Citations

Include unpublished citations

Flentke, G.R., Wilkie, T.E., Baulch, J., Huang, Y., Smith, S.M. (2024) Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 19:e0304557e0304557
Thomasova, D., Bruns, H.A., Kretschmer, V., Ebrahim, M., Romoli, S., Liapis, H., Kotb, A.M., Endlich, N., Anders, H.J. (2015) Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes. Journal of the American Society of Nephrology : JASN. 26(7):1513-23
Tao, T., Shi, H., Guan, Y., Huang, D., Chen, Y., Lane, D.P., Chen, J., and Peng, J. (2013) Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Research. 23(5):620-634
Guo, L., Chua, J., Vijayakumar, D., Lee, K.C., Lim, K., Eng, H., Ghadessy, F., Coomber, D., and Lane, D.P. (2010) Detection of the 113p53 protein isoform: A p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish. Cell cycle (Georgetown, Tex.). 9(10):1998-2007
Huang, C., Gu, S., Yu, P., Yu, F., Feng, C., Gao, N., and Du, J. (2010) Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Developmental Biology. 339(1):89-100
Bretaud, S., Allen, C., Ingham, P.W., and Bandmann, O. (2007) p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease. Journal of neurochemistry. 100(6):1626-1635
Robu, M.E., Larson, J.D., Nasevicius, A., Beiraghi, S., Brenner, C., Farber, S.A., and Ekker, S.C. (2007) p53 activation by knockdown technologies. PLoS Genetics. 3(5):e78
Langheinrich, U., Hennen, E., Stott, G., and Vacun, G. (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Current biology : CB. 12(23):2023-2028

1 - 8 of 8

Show