ZFIN Morpholino: MO1-kdrl

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-kdrl

No data available

Phenotype

Phenotype resulting from MO1-kdrl

Phenotype	Fish	Figures
intersegmental vessel absent, abnormal	WT + MO1-kdrl	Fig. 4 from Rottbauer et al., 2005
intersegmental vessel hypoplastic, abnormal	s843Tg + MO1-kdrl	Fig. 4 from Qiu et al., 2016

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Phenotype of all Fish created by or utilizing MO1-kdrl

Phenotype	Fish	Conditions	Figures
intersegmental vessel absent, abnormal	WT + MO1-kdrl	standard conditions	Fig. 4 from Rottbauer et al., 2005
intersegmental vessel hypoplastic, abnormal	s843Tg + MO1-kdrl	control	Fig. 4 from Qiu et al., 2016
liver ito cell decreased amount, abnormal	pd24Tg; s896Tg + MO1-kdrl	chemical treatment: semaxanib	Fig. 6 from Yin et al., 2012
intersegmental vessel absent, abnormal	y1Tg + MO1-kdrl + MO3-kdr	standard conditions	Fig. 5 from Jensen et al., 2015
intersegmental vessel decreased length, abnormal	y1Tg + MO1-kdrl + MO3-kdr	standard conditions	Fig. 5 from Jensen et al., 2015

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Citations

Include unpublished citations

Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
Tsao, K.C., Lin, Y.C., Chen, Y.T., Lai, S.L., Yang, R.B. (2021) Zebrafish scube1 and scube2 cooperate in promoting Vegfa signaling during embryonic vascularization. Cardiovascular research. 118(4):1074-1087
Toselli, C.M., Wilkinson, B.M., Paterson, J., Kieffer, T.J. (2019) Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation. Scientific Reports. 9:3594
Hasan, S.S., Tsaryk, R., Lange, M., Wisniewski, L., Moore, J.C., Lawson, N.D., Wojciechowska, K., Schnittler, H., Siekmann, A.F. (2017) Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature cell biology. 19(8):928-940
Hamm, M.J., Kirchmaier, B.C., Herzog, W. (2016) Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1. The Journal of cell biology. 215(3):415-430
Qiu, J., Fan, X., Wang, Y., Jin, H., Song, Y., Han, Y., Huang, S., Meng, Y., Tang, F., Meng, A. (2016) Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Journal of molecular cell biology. 8(4):288-301
Jensen, L.D., Nakamura, M., Bräutigam, L., Li, X., Liu, Y., Samani, N.J., Cao, Y. (2015) VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(44):E5944-53
Anton, H., Harlepp, S., Ramspacher, C., Wu, D., Monduc, F., Bhat, S., Liebling, M., Paoletti, C., Charvin, G., Freund, J.B., and Vermot, J. (2013) Pulse propagation by a capacitive mechanism drives embryonic blood flow. Development (Cambridge, England). 140(21):4426-34
Ba, Q., Duan, J., Tian, J.Q., Wang, Z.L., Chen, T., Li, X.G., Chen, P.Z., Wu, S.J., Xiang, L., Li, J.Q., Chu, R.A., and Wang, H. (2013) Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish. Acta Pharmacologica Sinica. 34(8):1101-7
Yin, C., Evason, K.J., Maher, J.J., and Stainier, D.Y. (2012) The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver. Hepatology (Baltimore, Md.). 56(5):1958-1970

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