ZFIN Morpholino: MO1-sox32

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-sox32

Expressed Gene	Anatomy	Figures
alcama	(not) pharyngeal pouch	Fig. 1 from Nechiporuk et al., 2005
fgf3	(not) pharyngeal pouch presumptive cephalic mesoderm	Fig. 4 from Nechiporuk et al., 2007 Fig. 2 from Nechiporuk et al., 2005
fgf8a	presumptive cephalic mesoderm	Fig. 4 from Nechiporuk et al., 2007
foxa3	(not) endoderm notochord	Fig. 4 from Stafford et al., 2006
foxi1	epibranchial placode facial ganglion glossopharyngeal ganglion midbrain hindbrain boundary presumptive cephalic mesoderm vagal ganglion 1 vagal ganglion 2 vagal ganglion 3 vagal ganglion 4 (all 9)	Fig. 4 from Nechiporuk et al., 2007 Fig. 5 from Nechiporuk et al., 2005

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Phenotype

Phenotype resulting from MO1-sox32

Phenotype	Fish	Figures
axial vasculature morphology, abnormal	y1Tg + MO1-sox32	Fig. S4 from Chung et al., 2011
blood circulation decreased rate, abnormal	y1Tg + MO1-sox32	Fig. 2 from Leslie et al., 2007
cranial ganglion maturation decreased process quality, abnormal	w37Tg + MO1-sox32	Fig. 3 from McCarroll et al., 2013
definitive hemopoiesis disrupted, abnormal	WT + MO1-sox32	Fig. 8 from Chung et al., 2011
ectodermal placode development decreased process quality, abnormal	AB + MO1-sox32	Fig. 3 from McCarroll et al., 2013

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Phenotype of all Fish created by or utilizing MO1-sox32

Phenotype	Fish	Conditions	Figures
ectodermal placode development decreased process quality, abnormal	AB + MO1-sox32	standard conditions	Fig. 3 from McCarroll et al., 2013
glossopharyngeal placode poorly differentiated, abnormal	AB + MO1-sox32	standard conditions	Fig. 3 from McCarroll et al., 2013
whole organism sox32 expression increased amount, abnormal	WT + MO1-sox32	standard conditions	Fig. 9 from Chung et al., 2011
mesodermal cell migration delayed, abnormal	WT + MO1-sox32	standard conditions	Fig. 8 from Chung et al., 2011
hematopoietic stem cell migration delayed, abnormal	WT + MO1-sox32	standard conditions	Fig. 8 from Chung et al., 2011

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Citations

Include unpublished citations

Petridou, N.I., Corominas-Murtra, B., Heisenberg, C.P., Hannezo, E. (2021) Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7):1914-1928.e19
Dalgin, G., Prince, V.E. (2020) Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Developmental Biology. 471:1-9
Čapek, D., Smutny, M., Tichy, A.M., Morri, M., Janovjak, H., Heisenberg, C.P. (2019) Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration. eLIFE. 8:
Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
Collins, M.M., Maischein, H.M., Dufourcq, P., Charpentier, M., Blader, P., Stainier, D.Y. (2018) Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration. eLIFE. 7:
Liu, Z., Woo, S., Weiner, O.D. (2018) Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation. Development (Cambridge, England). 145(17):
Barone, V., Lang, M., Krens, S.F.G., Pradhan, S.J., Shamipour, S., Sako, K., Sikora, M., Guet, C.C., Heisenberg, C.P. (2017) An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Developmental Cell. 43(2):198-211.e12
Krens, S.F.G., Veldhuis, J.H., Barone, V., Čapek, D., Maître, J.L., Brodland, G.W., Heisenberg, C.P. (2017) Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation. Development (Cambridge, England). 144:1798-1806
Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Čapek, D., Behrndt, M., Papusheva, E., Tada, M., Hof, B., Vicsek, T., Salbreux, G., Heisenberg, C.P. (2017) Friction forces position the neural anlage. Nature cell biology. 19(4):306-317
Perez-Camps, M., Tian, J., Chng, S.C., Sem, K.P., Sudhaharan, T., Teh, C., Wachsmuth, M., Korzh, V., Ahmed, S., Reversade, B. (2016) Quantitative imaging reveals real-time Pou5f3-Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish. eLIFE. 5

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