ZFIN Morpholino: MO1-ptgs2a

Target Location

Genome Build: GRCz11Chromosome: 2

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ptgs2a

No data available

Phenotype

Phenotype resulting from MO1-ptgs2a

Phenotype	Fish	Figures
brain hydrocephalic, abnormal	TU + MO1-ptgs2a	Fig. S3 from Marra et al., 2019
pericardium edematous, abnormal	TU + MO1-ptgs2a	Fig. S3 from Marra et al., 2019
pronephric duct cimap1b expression decreased distribution, abnormal	TU + MO1-ptgs2a	Fig. 1 from Marra et al., 2019
pronephric duct jag2b expression decreased distribution, abnormal	TU + MO1-ptgs2a	Fig. 2 from Marra et al., 2019
pronephric duct pax2a expression decreased distribution, abnormal	TU + MO1-ptgs2a	Fig. 2 from Marra et al., 2019

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Phenotype of all Fish created by or utilizing MO1-ptgs2a

Phenotype	Fish	Conditions	Figures
pronephric duct jag2b expression decreased distribution, abnormal	TU + MO1-ptgs2a	control	Fig. 2 from Marra et al., 2019
pronephric duct pax2a expression decreased distribution, abnormal	TU + MO1-ptgs2a	control	Fig. 2 from Marra et al., 2019
pronephric duct multi-ciliated epithelial cell has fewer parts of type multi-ciliated epithelial cell cilium, abnormal	TU + MO1-ptgs2a	control	Fig. 4 from Marra et al., 2019
pronephric duct cimap1b expression decreased distribution, abnormal	TU + MO1-ptgs2a	chemical treatment by environment: prostaglandin E2	Fig. 1 from Marra et al., 2019
brain hydrocephalic, abnormal	TU + MO1-ptgs2a	control	Fig. S3 from Marra et al., 2019

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Citations

Include unpublished citations

Marra, A.N., Adeeb, B.D., Chambers, B.E., Drummond, B.E., Ulrich, M., Addiego, A., Springer, M., Poureetezadi, S.J., Chambers, J.M., Ronshaugen, M., Wingert, R.A. (2019) Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Proceedings of the National Academy of Sciences of the United States of America. 116(17):8409-8418
Poureetezadi, S.J., Cheng, C.N., Chambers, J.M., Drummond, B.E., Wingert, R.A. (2016) Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development. eLIFE. 5
Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
Nissim, S., Sherwood, R.I., Wucherpfennig, J., Saunders, D., Harris, J.M., Esain, V., Carroll, K.J., Frechette, G.M., Kim, A.J., Hwang, K.L., Cutting, C.C., Elledge, S., North, T.E., and Goessling, W. (2014) Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Developmental Cell. 28(4):423-437
Eisinger, A.L., Nadauld, L.D., Shelton, D.N., Prescott, S.M., Stafforini, D.M., and Jones, D.A. (2007) Retinoic Acid Inhibits β-Catenin through Suppression of Cox-2: A role for truncated adenomatous polyposis coli. The Journal of biological chemistry. 282(40):29394-29400
North, T.E., Goessling, W., Walkley, C.R., Lengerke, C., Kopani, K.R., Lord, A.M., Weber, G.J., Bowman, T.V., Jang, I.H., Grosser, T., Fitzgerald, G.A., Daley, G.Q., Orkin, S.H., and Zon, L.I. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447(7147):1007-1011
Grosser, T., Yusuff, S., Cheskis, E., Pack, M.A., and FitzGerald, G.A. (2002) Developmental expression of functional cyclooxygenases in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 99(12):8418-8423

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