ZFIN Morpholino: MO1-efnb2a

Target Location

Genome Build: GRCz11Chromosome: 9

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-efnb2a

Expressed Gene	Anatomy	Figures
egr2b	rhombomere 3 rhombomere 5	Fig. 1 from Cooke et al., 2005
sema3gb	rhombomere	Fig. 1 from Cooke et al., 2005

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Phenotype

Phenotype resulting from MO1-efnb2a

Phenotype	Fish	Figures
blood vessel morphogenesis disrupted, abnormal	WT + MO1-efnb2a	Fig. 4 from Herbert et al., 2009
dorsal aorta aplastic, abnormal	WT + MO1-efnb2a	Fig. 4 from Herbert et al., 2009

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Phenotype of all Fish created by or utilizing MO1-efnb2a

Phenotype	Fish	Conditions	Figures
dorsal aorta aplastic, abnormal	WT + MO1-efnb2a	standard conditions	Fig. 4 from Herbert et al., 2009
blood vessel morphogenesis disrupted, abnormal	WT + MO1-efnb2a	standard conditions	Fig. 4 from Herbert et al., 2009
optic vesicle morphogenesis disrupted, abnormal	WT + MO1-efnb1 + MO1-efnb2a	standard conditions	Fig. 2 from Cavodeassi et al., 2013
trigeminal motor nucleus fused with trigeminal motor nucleus, abnormal	WT + MO1-efnb2a + MO1-epha4a	standard conditions	Fig. 1 from Cooke et al., 2005
rhombomere 5 rhombomere boundary formation process quality, abnormal	WT + MO1-efnb2a + MO1-epha4a	standard conditions	Fig. 1 from Cooke et al., 2005

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Citations

Include unpublished citations

Zhang, J.F., Jiang, Z., Liu, X., Meng, A. (2016) Eph-ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development (Cambridge, England). 143(14):2603-15
Cavodeassi, F., Ivanovitch, K., and Wilson, S.W. (2013) Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis. Development (Cambridge, England). 140(20):4193-4202
Kim, S.H., Schmitt, C.E., Woolls, M.J., Holland, M.B., Kim, J.D., and Jin, S.W. (2013) Vascular Endothelial Growth Factor Signaling Regulates the Segregation of Artery and Vein via ERK Activity during Vascular Development. Biochemical and Biophysical Research Communications. 430(4):1212-1216
Stevenson, T.J., Trinh, T., Kogelschatz, C., Fujimoto, E., Lush, M.E., Piotrowski, T., Brimley, C.J., and Bonkowsky, J.L. (2012) Hypoxia Disruption of Vertebrate CNS Pathfinding through EphrinB2 Is Rescued by Magnesium. PLoS Genetics. 8(4):e1002638
Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M., and Stainier, D.Y. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326(5950):294-298
Kemp, H.A., Cooke, J.E., and Moens, C.B. (2009) EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel. Developmental Biology. 327(2):313-326
Cooke, J.E., Kemp, H.A., and Moens, C.B. (2005) EphA4 Is Required for Cell Adhesion and Rhombomere-Boundary Formation in the Zebrafish. Current biology : CB. 15(6):536-542

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