ZFIN Morpholino: MO2-cxcl12a

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-cxcl12a

Expressed Gene	Anatomy	Figures
ackr3b	posterior lateral line primordium primary posterior lateral line primordium	Fig. 3 from Gamba et al., 2010 Fig. 9 from Dambly-Chaudière et al., 2007
anos1a	posterior lateral line primordium	Fig. 6 from Yanicostas et al., 2008
cxcr4b	posterior lateral line primordium	Fig. 3 from Gamba et al., 2010

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Phenotype

Phenotype resulting from MO2-cxcl12a

Phenotype	Fish	Figures
axon guidance disrupted, abnormal	zf103Tg + MO2-cxcl12a	Fig. 2 from Palevitch et al., 2010
melanophore stripe melanocyte decreased amount, abnormal	WT + MO2-cxcl12a	Fig. 10 from Svetic et al., 2007
neuromast primordium migration delayed, abnormal	WT + MO2-cxcl12a	Fig. 6 from Yanicostas et al., 2008
neuron migration disrupted, abnormal	zf103Tg + MO2-cxcl12a	Fig. 2 from Palevitch et al., 2010
posterior lateral line neuromast primordium migration disrupted, abnormal	WT + MO2-cxcl12a	Fig. 9 from Dambly-Chaudière et al., 2007

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Phenotype of all Fish created by or utilizing MO2-cxcl12a

Phenotype	Fish	Conditions	Figures
posterior lateral line neuromast primordium migration disrupted, abnormal	WT + MO2-cxcl12a	standard conditions	Fig. 9 from Dambly-Chaudière et al., 2007
neuromast primordium migration delayed, abnormal	WT + MO2-cxcl12a	standard conditions	Fig. 6 from Yanicostas et al., 2008
posterior lateral line primordium physical object quality, abnormal	WT + MO2-cxcl12a	standard conditions	Fig. 3 from Gamba et al., 2010
melanophore stripe melanocyte decreased amount, abnormal	WT + MO2-cxcl12a	standard conditions	Fig. 10 from Svetic et al., 2007
posterior lateral line neuromast primordium migration process quality, abnormal	WT + MO2-cxcl12a	standard conditions	Fig. 3 from Gamba et al., 2010

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Citations

Include unpublished citations

Wei, Z., Hong, Q., Ding, Z., Liu, J. (2023) cxcl12a plays an essential role in pharyngeal cartilage development. Frontiers in cell and developmental biology. 11:12432651243265
Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L. (2019) Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nature cell biology. 21:966-977
Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F. (2014) Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Developmental Biology. 385(2):316-27
Venkiteswaran, G., Lewellis, S.W., Wang, J., Reynolds, E., Nicholson, C., and Knaut, H. (2013) Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue. Cell. 155(3):674-687
Gamba, L., Cubedo, N., Ghysen, A., Lutfalla, G., and Dambly-Chaudière, C. (2010) Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system. Proceedings of the National Academy of Sciences of the United States of America. 107(14):6358-6363
Palevitch, O., Abraham, E., Borodovsky, N., Levkowitz, G., Zohar, Y., and Gothilf, Y. (2010) Cxcl12a-Cxcr4b signaling is important for proper development of the forebrain GnRH system in zebrafish. General and comparative endocrinology. 165(2):262-268
Cubedo, N., Cerdan, E., Sapede, D., and Rossel, M. (2009) CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons. Molecular and cellular neurosciences. 40(4):474-484
Aman, A., and Piotrowski, T. (2008) Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Developmental Cell. 15(5):749-761
Yanicostas, C., Ernest, S., Dayraud, C., Petit, C., and Soussi-Yanicostas, N. (2008) Essential requirement for zebrafish anosmin-1a in the migration of the posterior lateral line primordium. Developmental Biology. 320(2):469-479
Chong, S.W., Nguyet, L.M., Jiang, Y.J., and Korzh, V. (2007) The chemokine, Sdf-1, and its receptor, Cxcr4, are required for formation of muscle in zebrafish. BMC Developmental Biology. 7(1):54

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