Gene
cxcl12a
- ID
- ZDB-GENE-030318-1
- Name
- chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
- Symbol
- cxcl12a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables chemoattractant activity. Acts upstream of or within several processes, including nervous system development; regulation of cell migration; and regulation of chemotaxis. Is active in migrasome. Is expressed in several structures, including brain; mesoderm; myoseptum; reproductive system; and sensory system. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 83 figures from 68 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 22 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {AIDS, resistance to} | 609423 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC Chemokine domain |
|---|---|---|---|---|
|
UniProtKB:Q8AV10
|
99 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl12a-201
(1)
|
Ensembl | 3,041 nt |
Interactions and Pathways
Plasmids
No data available