Gene
cxcl12a
- ID
- ZDB-GENE-030318-1
- Name
- chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
- Symbol
- cxcl12a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables chemoattractant activity. Acts upstream of or within several processes, including nervous system development; regulation of cell migration; and regulation of chemotaxis. Is active in migrasome. Is expressed in several structures, including brain; mesoderm; myoseptum; reproductive system; and sensory system. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 83 figures from 68 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 22 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ox190 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa12849 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35516 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| szy205 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| t30516 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tsu4cd | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| u766 | unknown | Unknown | Unknown | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {AIDS, resistance to} | 609423 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC Chemokine domain |
|---|---|---|---|---|---|
| UniProtKB:Q8AV10 | InterPro | 99 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl12a-201
(1)
|
Ensembl | 3,041 nt |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(hsp70l:cxcl12a) |
|
| 1 | (2) | |
| TgBAC(cxcl12a:Cerulean) |
|
| 1 | Xu et al., 2014 | |
| TgBAC(cxcl12a:cxcl12a-3xFLAG-4xHA,cryaa:DsRed) |
|
| 1 | Fuentes et al., 2016 | |
| TgBAC(cxcl12a:cxcl12a-EGFP-2A-mKate2-CAAX) |
|
| 1 | Wong et al., 2020 | |
| TgBAC(cxcl12a:cxcl12a-EGFP,cryaa:DsRed) |
|
| 2 | (5) | |
| TgBAC(cxcl12a:cxcl12a-TagRFP-sfGFP) |
|
| 1 | Wong et al., 2020 | |
| Tg(cxcl12a:BFP-2A-Hsa.CXCL12) |
|
| 1 | Rajan et al., 2019 | |
| Tg(cxcl12a:DsRed2) |
|
| 2 | (8) | |
| Tg(hsp70l:cxcl12a) |
|
| 1 | (11) | |
| Tg(hsp70l:cxcl12a,EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-228B19 | ZFIN Curated Data | |
| Contains | STS | chunp30664 | ||
| Encodes | EST | fa55e10 | ||
| Encodes | EST | fc16h12 | ||
| Encodes | cDNA | MGC:123091 | ZFIN Curated Data | |
| Is Hybridized by | EST | fj84c02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178307 (1) | 1521 nt | ||
| Genomic | GenBank:CR762493 (2) | 168643 nt | ||
| Polypeptide | UniProtKB:Q8AV10 (1) | 99 aa |
- Borges, A., Pinto-Teixeira, F., Wibowo, I., Pogoda, H.M., Hammerschmidt, M., Kawakami, K., López-Schier, H., Miranda-Rodríguez, J.R. (2024) Incoherent collective cell chemotaxis underlies organ dysmorphia in a model of branchio-oto-renal syndrome. microPublication. Biology. 2024:
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Juan, T., Bellec, M., Cardoso, B., Athéa, H., Fukuda, N., Albu, M., Günther, S., Looso, M., Stainier, D.Y.R. (2024) Control of cardiac contractions using Cre-lox and degron strategies in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 121:e2309842121e2309842121
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Wright, K., Han, D.J., Song, R., de Silva, K., Plain, K.M., Purdie, A.C., Shepherd, A., Chin, M., Hortle, E., Wong, J.J., Britton, W.J., Oehlers, S.H. (2024) Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Life science alliance. 7(4):
- Arthi, B., Chellathai, D. (2023) Effects of vasicine in neuroinflammatory zebrafish model. Bioinformation. 19:595604595-604
- Collier, A.D., Yasmin, N., Karatayev, O., Abdulai, A.R., Yu, B., Khalizova, N., Fam, M., Leibowitz, S.F. (2023) Neuronal chemokine concentration gradients mediate effects of embryonic ethanol exposure on ectopic hypocretin/orexin neurons and behavior in zebrafish. Scientific Reports. 13:14471447
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Wei, Z., Hong, Q., Ding, Z., Liu, J. (2023) cxcl12a plays an essential role in pharyngeal cartilage development. Frontiers in cell and developmental biology. 11:12432651243265
- Westerich, K.J., Reinecke, S., Emich, J., Wyrwoll, M.J., Stallmeyer, B., Meyer, M., Oud, M.S., Fietz, D., Pilatz, A., Kliesch, S., Reichman-Fried, M., Tarbashevich, K., Limon, T., Stehling, M., Friedrich, C., Tüttelmann, F., Raz, E. (2023) Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Human reproduction (Oxford, England). 38(4):655-670
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