Gene

cxcl12a

ID
ZDB-GENE-030318-1
Name
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
Symbol
cxcl12a Nomenclature History
Previous Names
  • cxcl12 (1)
  • SDF-1 (1)
  • sdf-1a (1)
  • sdf1a (1)
  • unm t30516
  • unm_t30516
  • wu:fa55e10 (1)
  • wu:fc16h12 (1)
  • wu:fj84c02 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables chemoattractant activity. Acts upstream of or within several processes, including fin regeneration; nervous system development; and regulation of cell migration. Predicted to be located in extracellular space. Is expressed in several structures, including brain; mesoderm; myoseptum; neural rod; and sensory system. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
74 figures from 59 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 22 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcl12a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{AIDS, resistance to} 609423
Associated With cxcl12a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001811 Chemokine interleukin-8-like domain
Domain IPR033899 CXC Chemokine domain
Family IPR039813 Stromal cell-derived factor 1
Homologous_superfamily IPR036048 Chemokine interleukin-8-like superfamily
Domain Details Per Protein
Protein Length Chemokine interleukin-8-like domain Chemokine interleukin-8-like superfamily CXC Chemokine domain Stromal cell-derived factor 1
UniProtKB:Q8AV10 99
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations