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Hoffmann et al., 2026 - Linking shox/shox2 deficiency with fgfr3 gain-of-function and natriuretic peptides

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Figure 2

Shox and shox2 knockdown affect expression levels of the natriuretic peptide genes nppa, nppb and nppc in a tissue-specific manner. Relative expression levels upon shox(A), shox2(B) and shox/shox2(C) knockdown in fin (n=3), heart (n=4-5), head (n=4) and whole embryo (n=6). Statistical significance was determined by multiple unpaired t-tests adjusted by the two-stage step-up method of Benjamini, Krieger, and Yekutieli (adjusted values of P are indicated as black asterisks, nominal significant values of P are indicated as colored asterisks). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). MO = morpholino, hpf = hours post fertilization, n = number of independent experiments.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)