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Chen et al., 2026 - Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish

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FIGURE 1 UPR^mt is activated during muscle atrophy in zebrafish larvae. (a) qRT-PCR analysis of dexamethasone (DEXA)-treated zebrafish larvae, showing the expression of the atrophy genes fbxo32 and trim63a (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (b) Bright-field images of myotome from DEXA-treated zebrafish larvae at 6 dpf. Arrow indicates disorganized muscle fibers. Scale bar represents 0.1 mm. (c) Fluorescence images of the UPR^mt reporter zebrafish treated with DEXA. Arrows indicate elevated fluorescent signals in the skeletal muscle. Scale bar represents 1 mm. (d) qRT-PCR analysis of DEXA-treated zebrafish larvae showing the expression of the UPR^mt genes hspd1, hspa9, lonp1, and clpp (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (e) Western blot and quantification of poly-ubiquitinated proteins in the detergent-soluble and -insoluble fractions of the protein lysates from DEXA-treated zebrafish larvae (*p < 0.05, t-test, two-tailed, error bar indicates s.d.).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol