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ZDB-IMAGE-251229-55

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Nguyen et al., 2025 - Functional divergence of zebrafish keap1 paralogs revealed by CRISPR/Cas9-mediated gene editing: a specialized role for keap1b in inflammation

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Fig. 3 Constitutive activation of Nrf2 target genes in keap1 mutants. Relative mRNA expression of A gstp1.2 and B prdx1 in 4 dpf larvae of different genotypes, with or without H₂O₂ treatment. In the absence of oxidative stress, both keap1a−/− and keap1b−/− mutants show significantly elevated basal expression of these Nrf2 target genes, indicating constitutive pathway activation due to loss of Keap1-mediated Nrf2 repression. This constitutive activation is completely abolished in nfe2l2a−/− larvae, confirming these genes are bona fide Nrf2 targets. Expression is normalized to ef1a and relative to the untreated WT group. Data are mean ± SEM (n = 3). *p < 0.05, **p < 0.01

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Transgenic. Res.